arXiv:2607. 27690v2 Announce Type: replace-cross Abstract: We introduce LabEvolver, a training-free framework that equips safe and grounded wet-lab agents with episodic memory from execution experience.
By Jingya Wang, Yuyang Gao, Liuzhenghao Lv, Yonghong Tian, Yuyang Liu
arXiv:2606. 13578v1 Announce Type: cross Abstract: Scientific laboratories increasingly rely on AI systems to reason about experiments, but the physical act of doing science remains largely outside their reach.
By Baochang Ren, Xinjie Liu, Xi Chen, Yanshuo Liu, Chenxi Li, Daqi Gao, Zeqin Su, Jintao Xing, Zirui Xue, Rui Li, Xiangyu Zhao, Shuofei Qiao, Minting Pan, Wangmeng Zuo, Lei Bai, Dongzhan Zhou, Ningyu Zhang, Huajun Chen
LabFactory is a framework that transforms a scientific brief into an executable AI lab, integrating models, knowledge resources, tools, and a controller behind a fixed interface. The builder packages the lab in a metered workspace, and a separate host evaluates the delivered artifact on held‑out inputs, ensuring the system itself is the evaluation target. Across 28 constructions in seven scientific domains, the delivered labs surpassed reference values on all 33 subtests, demonstrating that an AI agent can fully realize a scientific brief into a working, inspectable lab.
By Jinge Wu, Hongjian Zhou, Mingde Zeng, Jiayuan Zhu, Junde Wu, Jiazhen Pan, Lei Clifton, Andrew Liu, David A. Clifton
arXiv:2508.05427v2 Announce Type: replace
Abstract: Large language models (LLMs) are beginning to reshape how organic-synthesis workflows are represented, queried, planned, and connected to experimen...
By Kartar Kumar, Rajesh Kumar, Nikesh Lagun
arXiv:2606. 31763v1 Announce Type: new Abstract: Autonomous wet-lab experimentation requires more than plausible protocol text: biological intent, quantitative procedures, device constraints and experimental feedback must remain aligned from protocol and SOP design to code and physical execution.
By Yankai Jiang, Weiting Tang, Haoran Sun, Zhenyu Tang, Yuejie Hou, Yingnan Han, Rubo Wang, Yueyuxiao Yang, Cheng Liang, Lilong Wang, Wenjie Lou, Xiaosong Wang, Lei Bai, Meng Yang
arXiv:2607. 19336v1 Announce Type: new Abstract: Agentic systems large language model (LLM) based architectures capable of reasoning, planning, acting, and coordinating with tools and other agents are rapidly transitioning from research prototypes to production scale deployments across domains such as software engineering, scientific discovery, and finance.
By Grace Hui Yang, Pranav N. Venkit, Hooman Sedghamiz, Enrico Santus, Victor Dibia, Ioana Baldini
OpenAI4S is an open‑source scientific research agent that treats code as action and science as sessions, combining a persistent computing runtime with structured session management. It uses tool calls for orchestration, executes code cells in persistent Python and R kernels, and records an append‑only Action Ledger, per‑cell execution logs, versioned artifacts, environment snapshots, and workspace checkpoints to preserve provenance and enable session recovery, branching, and extension. Evaluated on 36 research scenarios—including retrosynthesis, molecular dynamics, and protein design—OpenAI4S achieved a higher overall score (7.83) than a general‑purpose coding harness, especially on long‑horizon, computation‑intensive workflows, though reproducibility remains an open challenge.
whyItMatters":"The system demonstrates that persistent execution coupled with session‑level provenance can enhance the reliability of AI‑assisted scientific workflows, as evidenced by its superior performance across diverse research scenarios."
By Gongbo Zhang, Hao Li, Yu Wang, Mujie Lin, Liuzhenghao Lv, Yicheng Mao, Yimi Wang, Jun Zhu, Minhan Tang, Zhengxiang Jiang, Yusong Wang, Jiayu Yao, Kunpeng Ning, Dawei Pang, Yonghong Tian, OpenAI4S Community, Yuyang Liu, Li Yuan
arXiv:2601. 21570v2 Announce Type: replace Abstract: The field of Embodied AI is witnessing a rapid evolution toward general-purpose robotic systems, fueled by high-fidelity simulation and large-scale data collection.
By Zixing Lei, Genjia Liu, Yuanshuo Zhang, Qipeng Liu, Yuzhu Cai, Sixiang Chen, Jixian Wu, Yunhong Wang, Weixin Li, Chuan Wen, Bo Zhao, Shanghang Zhang, Wenzhao Lian, Siheng Chen
La Agente ’Optima is an agentic framework that builds and manages Bayesian optimization campaigns for self‑driving laboratories, separating large language model reasoning from campaign execution. It maintains a persistent optimization state, allowing consistent repetitive loops and auditable decisions, and only returns control to the agent when interpretation or revision is needed. In tests on digital discovery tasks and physical platforms, it corrected measurement failures, improved yields, and recommended formulation changes, outperforming human‑directed campaigns in cost and material usage.
By Marcel M\"uller, Jiaru Bai, Willi Gottstein, Abhijoy Mandal, Mohammad Nazeri, Elia Savino, Yanlin Fang, Sujoy Das, Sergio Pablo Garc\'ia Carrillo, Yeonghun Kang, Juan B. P\'erez-S\'anchez, Simone Pilon, Martin Fitzner, Timothy No\"el, Frank Gu, Varinia Bernales, Al\'an Aspuru-Guzik
arXiv:2609. 30971v1 Announce Type: new Abstract: Embodied agents offer a promising route to automating scientific experimentation, yet their progress is constrained by the lack of reliable and systematic evaluation environments.
By Maokai Qin, Chuan Qin, Qi Zhang, Dianyu Liu, Zirui Liu, Hongting Niu, Yuanchun Zhou, Hengshu Zhu
OSWorld-Science is a benchmark and evaluation environment for computer-using agents that use visual language models (VLMs) to perform scientific software tasks. It includes 12 VLMs and 146 high-quality tasks across domains such as molecular drawing, pathology image analysis, statistical computing, and physical simulation, with artifact-based evaluation and a harness that logs interactions and supports model comparison. The benchmark was developed through expert proposals and iterative human–AI co‑design, and results show that current VLMs still struggle with key scientific questions, offering insights into factors like language, reasoning, and context length.
By Dingyuan Dai, Heli Qi, Lei Liu, Yinxi Li, Baiding Chen, Zijun Dou, Qingcheng Zeng, Qi Kang, Oliver Sun, Eric Wang, Bo Zhou, Haixin Wang, Yufan Du, Shi Bo, Ruihan Lin, Mengqi Yuan, Dunjie Lu, Steven Dillmann, Yiming Shi, Tina Su, Amy Xin, Minghao Liu, Xi Wang, Xu Huang, Ge Zhang, Pengyu Nie, Zhen Yang, Jie Tang, Juanzi Li, Weihao Xuan, Tianyu Liu
arXiv:2510. 19771v4 Announce Type: replace Abstract: LLM-based agents are increasingly moving towards proactivity: rather than awaiting instruction, they exercise agency to anticipate user needs and solve them autonomously.
By Gil Pasternak, Dheeraj Rajagopal, Julia White, Dhruv Atreja, Matthew Thomas, George Hurn-Maloney, Ash Lewis