arXiv Machine Learning

Aligning Language Models with Observational Data: Opportunities and Risks from a Causal Perspective

The paper discusses how large language models (LLMs) can be fine‑tuned with observational data to improve alignment with human preferences and business goals. It highlights that directly using such data can cause models to learn spurious correlations, and introduces DeconfoundLM, a method that removes known confounders from reward signals. Experiments show that DeconfoundLM better recovers causal relationships and outperforms baseline methods by over 16% in objective score when confounding is present.

arXiv AI
Sep 2

Medical Causal Hypothesis Verification with Large Language Models

The paper "Medical Causal Hypothesis Verification with Large Language Models" reports a small-scale study evaluating eight LLMs on 17 medical causal hypotheses. The authors introduce an evaluation framework and annotate 1,067 evidence points across six criteria, using nine metrics to assess performance. Results show that while LLMs have strong recall, they frequently fail to provide valid scientific articles, evidence, or reject unsupported hypotheses, revealing a critical limitation for their use in healthcare.

By Safiyyah Ahmed, Abrar Ansari, Md Aminul Islam, Elena Zheleva
arXiv Machine Learning
Jul 17

Addressing Benchmarking Gaps in Large Language Models for Health and Medicine with Dynamic Red-Teaming

arXiv:2508. 00923v3 Announce Type: replace Abstract: Large language models (LLMs) are increasingly used to answer health-related questions and support healthcare workflows, yet evidence for their safety still relies heavily on static benchmarks that can rapidly become obsolete or be optimized against.

By Jiazhen Pan (Cherise), Bailiang Jian (Cherise), Paul Hager (Cherise), Yundi Zhang (Cherise), Che Liu (Cherise), Friederike Jungmann (Cherise), Hongwei Bran Li (Cherise), Julian Canisius (Cherise), Chenyu You (Cherise), Junde Wu (Cherise), Jiayuan Zhu (Cherise), Fenglin Liu (Cherise), Yuyuan Liu (Cherise), Niklas Bubeck (Cherise), Moritz Knolle (Cherise), Chen (Cherise), Chen (Cherise), Christian Wachinger, Zhenyu Gong, Cheng Ouyang, Georgios Kaissis, Benedikt Wiestler, Daniel Rueckert
arXiv AI
Aug 6

Memorization in Large Language Models in Medicine: Prevalence, Characteristics, and Implications

arXiv:2509. 08604v5 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have demonstrated significant potential in medicine, with many studies adapting them through continued pre-training or fine-tuning on medical data to enhance domain-specific accuracy and safety.

By Anran Li, Lingfei Qian, Mengmeng Du, Yu Yin, Yan Hu, Zihao Sun, Yihang Fu, Hyunjae Kim, Erica Stutz, Xuguang Ai, Qianqian Xie, Rui Zhu, Jimin Huang, Yifan Yang, Siru Liu, Yih-Chung Tham, Lucila Ohno-Machado, Hyunghoon Cho, Zhiyong Lu, Hua Xu, Qingyu Chen
arXiv AI
Aug 26

From Causal Plausibility to Causal Reliability: Evaluating LLMs as Calibrated Direct Causal-Edge Classifiers

The study evaluates 12 instruction‑tuned open‑weight LLMs on six causal‑graph benchmarks, testing five prompting strategies and four confidence sources. Findings show that LLMs tend to over‑predict edges, misclassify indirect or reversed edges as direct, and exhibit high over‑confidence, while conventional confidence estimates are unreliable and agreement signals offer limited improvement. The results suggest LLMs should be used as externally validated soft causal priors rather than definitive causal‑structure evidence.

By Amit Kumar, Elnur Adl Zarabi, Suranjana Trivedy, Zhiqian Chen, Lei Zhang, Kaiqun Fu, Taoran Ji
arXiv AI
Sep 7

A Removal Based Approach to Improve LLM Faithfulness at Test-Time

The paper proposes a test‑time method to enhance the faithfulness of large language model (LLM) explanations by removing concepts not credited in the model’s explanation before re‑querying the model. This approach targets incompleteness—omissions of influential factors—rather than unsoundness, and is model‑agnostic, requiring no changes to model weights. Experiments across two datasets and multiple model families show improved faithfulness compared to standard prompting and faithfulness‑encouraging prompts.

By Qinglan Luo, S M A Nahian, John Guttag, S. Mazdak Abulnaga, Katie Matton