The study investigates how a large language model, Gemma-3-27B-PT, internally represents depressive symptoms. By applying mechanistic interpretability methods to the model’s residual stream, researchers found that symptom groups are geometrically distinct at layer 21, and that projected symptom vectors align with clinician-annotated rankings across mood, somatic, and suicidality dimensions. Additionally, a single depression vector at this layer can differentiate depressive from non-depressive text with an AUC of 0.789, suggesting a potential emotional valence gate for symptom projection.
By Fangyi Zhu, Ajay Subramanian, Allison Constant, Camille Wang, Ravish Gupta, Corey J. Keller
arXiv:2607. 21496v1 Announce Type: cross Abstract: Cognitive impairment (CI) is a growing public health concern.
By Yingchao Huang, Xin Wang, Yuhan Su, Shanshan Yao
arXiv:2606. 19640v1 Announce Type: cross Abstract: AI and large language models (LLMs) have emerged as promising tools to address global mental health challenges.
By Yunkai Xu, Saeed Abdullah
arXiv:2609.01833v1 Announce Type: new
Abstract: Sentence-level recognition of depression symptoms is challenging because similar expressions can differ in symptom relevance, and language-model infere...
By Weiming Li, Catarina Barata, Miguel Constante, Joao Sanches
arXiv:2608.30857v1 Announce Type: cross
Abstract: Depression and anxiety in older adults with Mild Cognitive Impairment (MCI) are frequently underdiagnosed due to limited access to care. Multimodal a...
By Merna Bibars, Bolaji Omofojoye, Allan I. Levey, Rachel Hershenberg, Gari D. Clifford, Hyeokhyen Kwon
arXiv:2608.29582v1 Announce Type: cross
Abstract: Current evaluations of large language models (LLMs) primarily focus on factual knowledge retrieval, overlooking the fundamental challenge of navigati...
By Yi Yu, Bo Wang, Chong Feng, Ge Shi, Xia Liu, Ziyi Yang, Xuewen Shi
arXiv:2608. 07316v1 Announce Type: cross Abstract: Natural Language Processing (NLP) models predicting mental health outcomes rarely specify what they measure: contextual knowledge, emotional content, or syntactic structure.
By Edoardo Sebastiano De Duro, Emma Franchino, Massimo Stella
arXiv:2606. 28798v1 Announce Type: new Abstract: Objective: ICD codes are central to reimbursement, research, and population health surveillance, yet automated coding systems often struggle to integrate diagnostic signals from both clinical narratives and structured electronic health record (EHR) variables.
By Chengyuan Liu, Xinyue Zhang, Yao Li, Guanting Chen
arXiv:2608. 16507v1 Announce Type: new Abstract: Due to the limited amount of information, modeling longitudinal rare-disease data can benefit from integrating clinical knowledge.
By Clemens Sch\"achter, Astrid Pechmann, Janbernd Kirschner, Jan Hasenauer, Harald Binder
arXiv:2606. 18571v1 Announce Type: new Abstract: Mild Cognitive Impairment (MCI) is a medical condition characterized by a noticeable decline in memory, language, or thinking abilities.
By William Nguyen, Jiali Cheng, Hadi Amiri
The study introduces a clinician‑in‑the‑loop benchmark to assess whether large language models can generate evidence‑grounded Brief Hierarchical Taxonomy of Psychopathology (B‑HiTOP) item profiles from multimodal data, including passive sensing, ecological momentary assessment, and questionnaires. Using the GLOBEM dataset, the authors create 14,592 participant‑day instances aligned to 29 B‑HiTOP items across five spectra, and evaluate evidence compatibility rather than diagnostic accuracy. Two‑stage prediction improves compatibility for EMA and questionnaire evidence but reduces it for passive sensing and combined evidence, yielding more conservative score distributions across models, spectra, and evidence settings.
By Xiyun Hu, Xiangyuan Xue, Yuting Lyu, Hanya Shao, Jingping Nie
arXiv:2607. 25679v1 Announce Type: cross Abstract: Multimodal behavioral analysis offers a scalable approach to assessing depression, anxiety, and stress, yet generic fusion models often ignore the psychometric structure of questionnaire labels.
By Shiyu Teng, Haichen Yu, Jiaqing Liu, Hao Sun, Yu Song, Shurong Chai, Ruibo Hou, Lanfen Lin, Yen-Wei Chen