arXiv Computation and Language

Candidate Generation and Definition-Guided Verification for Sentence-Level Depression Symptom Recognition

The paper introduces a two‑stage framework for recognizing depression symptoms at the sentence level. First, a contrastively fine‑tuned sentence encoder generates a symptom candidate for each sentence. Then, a fine‑tuned language model verifies the candidate’s presence or absence by comparing the sentence, its context, and a diagnostic definition, ensuring the model’s judgment aligns with that definition before responding.

Hugging Face Trending Papers
Jul 16

Self-Evolving Human-Centered Framework for Explainable Depression Symptom Annotation

Annotation quality is a major bottleneck in building reliable and explainable artificial intelligence (XAI) systems for mental health research. In depression-related datasets, labels are often assigned without structured evidence, symptom-level justification, or traceable alignment with the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), limiting both transparency and downstream model interpretability.

arXiv AI
Sep 3

Interpretable Symptom Vectors for Depression in a Large Language Model

The study investigates how a large language model, Gemma-3-27B-PT, internally represents depressive symptoms. By applying mechanistic interpretability methods to the model’s residual stream, researchers found that symptom groups are geometrically distinct at layer 21, and that projected symptom vectors align with clinician-annotated rankings across mood, somatic, and suicidality dimensions. Additionally, a single depression vector at this layer can differentiate depressive from non-depressive text with an AUC of 0.789, suggesting a potential emotional valence gate for symptom projection.

By Fangyi Zhu, Ajay Subramanian, Allison Constant, Camille Wang, Ravish Gupta, Corey J. Keller
arXiv Machine Learning
Aug 31

Multilingual Lexical Feature Analysis of Spoken Language for Predicting Major Depression Symptom Severity

arXiv:2511.07011v2 Announce Type: replace-cross Abstract: Background: Remotely captured spoken language could provide objective, regular indicators of depression symptom severity. However, research t...

By Anastasiia Tokareva, Judith Dineley, Zoe Firth, Pauline Conde, Faith Matcham, Sara Siddi, Femke Lamers, Ewan Carr, Carolin Oetzmann, Daniel Leightley, Yuezhou Zhang, Amos A. Folarin, Josep Maria Haro, Brenda W. J. H. Penninx, Raquel Bailon, Srinivasan Vairavan, Til Wykes, Richard J. B. Dobson, Vaibhav A. Narayan, Matthew Hotopf, Nicholas Cummins, The RADAR-CNS Consortium
arXiv Computation and Language
Aug 21

Explainable Multimodal Depression Recognition in Clinical Interviews via PHQ-Aligned Symptom Summarization

arXiv:2501. 16106v2 Announce Type: replace Abstract: Recent advances in multimodal depression recognition for clinical interviews (MDRC) have demonstrated the potential of AI systems by integrating textual, acoustic, and facial cues.

By Wenjie Zheng, Qiming Xie, Jianfei Yu, Yang Wang, Lei Cao, Fei Wang, Shijin Wang, Rui Xia, Chengqing Zong
arXiv AI
Sep 18

When Consistency Becomes Bias: Interviewer Effects in Semi-Structured Clinical Interviews

The paper examines automatic depression detection from doctor‑patient conversations and finds that models trained on semi‑structured interview data can achieve high accuracy by exploiting fixed interviewer prompts rather than the participants’ language. Across three datasets (ANDROIDS, DAIC‑WOZ, E‑DAIC), the authors show that restricting models to participant utterances distributes decision evidence more broadly and reflects genuine linguistic cues. The study highlights a cross‑dataset, architecture‑agnostic bias introduced by interviewer prompts and calls for analyses that localize decision evidence by time and speaker to ensure models learn from participants’ language.

By Hasindri Watawana, Sergio Burdisso, Diego A. Moreno-Galv\'an, Fernando S\'anchez-Vega, A. Pastor L\'opez-Monroy, Petr Motlicek, Esa\'u Villatoro-Tello
arXiv AI
Aug 18

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

arXiv:2505. 14107v5 Announce Type: replace-cross Abstract: The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios.

By Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang
arXiv Computation and Language
Aug 27

MTDiag: A Multi-Turn Diagnostic Dataset Towards Clinically Meaningful LLM Evaluation

MTDiag is a newly released multi-turn diagnostic dialogue dataset designed to evaluate large language models (LLMs) in clinically meaningful ways. It is built from DDXPlus, MIMIC-IV, and AJCR case reports, covering both common emergency department presentations and rare conditions, and normalizes cases into a canonical schema using UMLS concept identifiers and ICD-10 codes. The dataset includes a UserLM‑8B utterance‑generation pipeline and physician‑validated natural‑language utterances, and introduces clinical knowledge‑grounded metrics that go beyond simple diagnostic accuracy for multi‑turn differential diagnosis tasks.

By Pia Chouayfati, Alexander M. Fichtl, Miriam Ansch\"utz, George Doumat, Georg Groh