arXiv:2606. 07640v1 Announce Type: cross Abstract: This study investigates the trade-offs between fidelity, privacy, and utility in synthetic data generation under conditions of data scarcity and privacy sensitivity.
By Borja Arroyo Galende, Alejandro Almod\'ovar, Patricia A. Apell\'aniz, Juan Parras, Silvia Uribe, Santiago Zazo
DeepSSIM++ is a self‑supervised similarity metric designed to audit memorization in medical generative models at scale. It aggregates multi‑scale features and uses anatomy‑preserving augmentations to create an embedding space where cosine similarity approximates SSIM, removing the need for exact pixel‑level registration. Compared to existing baselines, DeepSSIM++ improves Macro F1 by 33–46 percentage points and speeds up large‑scale similarity computation by several orders of magnitude.
By Antonio Scardace, Francesco Guarnera, Sebastiano Battiato, Daniele Rav\`i
arXiv:2607. 02998v2 Announce Type: replace-cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2607. 02998v1 Announce Type: cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.
By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2606. 07036v1 Announce Type: cross Abstract: Synthetic histopathology image generation addresses critical challenges in computational pathology, including patient privacy and the growing need for large-scale training data for foundation models.
By Won June Cho, Daeky Jeong, Hyeongyeol Lim, Hongjun Yoon
arXiv:2607. 08867v1 Announce Type: cross Abstract: Cloud-based deep learning enables large-scale medical image analysis but raises significant privacy concerns when sensitive patient images are outsourced for model development.
By Jason Rojas, Jiajie He, Yash Patel, Yuechun Gu, Zeyun Yu, Keke Chen
The paper introduces Flow-Based Distribution Matching (FBDM), a non‑adversarial framework that learns self‑supervised representations using explicit geometric references and spherical conditional velocity regression. FBDM assigns augmented image views to shared target references while limiting reference usage, and employs an alignment loss to bring view representations closer. Experiments on datasets from CIFAR to ImageNet demonstrate that FBDM performs nearly as well as adversarial DM, outperforms existing SSL methods, and achieves a 1.48‑ to 1.83‑fold speedup with minimal GPU memory increase, while a theoretical analysis bounds downstream misclassification rates in terms of the pretraining loss.
By Yuling Jiao, Wensen Ma, Houduo Qi, Defeng Sun
The paper introduces Differential Privacy Representation Geometry for Medical Imaging (DP‑RGMI), a framework that interprets differential privacy as a structured transformation of representation space. DP‑RGMI decomposes performance loss into encoder geometry—measured by representation displacement and spectral effective dimension—and task‑head utilization, quantified by the gap between linear‑probe and end‑to‑end utility. Across 594,000 chest X‑ray images from four datasets, the study finds that differential privacy consistently creates a utilization gap even when linear separability remains, while displacement and spectral dimension vary non‑monotonically with initialization and dataset, indicating that privacy alters representation anisotropy rather than uniformly collapsing features.
By Soroosh Tayebi Arasteh, Marziyeh Mohammadi, Sven Nebelung, Daniel Truhn
arXiv:2601. 19618v2 Announce Type: replace-cross Abstract: Differential privacy protects the patients whose images train medical imaging models, but it lowers diagnostic accuracy, and the initialization is the strongest known remedy.
By Soroosh Tayebi Arasteh, Mina Farajiamiri, Mahshad Lotfinia, Behrus Hinrichs-Puladi, Jonas Bienzeisler, Mohamed Alhaskir, Mirabela Rusu, Christiane Kuhl, Sven Nebelung, Daniel Truhn
The paper introduces StyleGANCA, a lightweight neural cellular automata (NCA) based generative adversarial network designed for medical image synthesis. By combining a StyleGAN-inspired mapping network with adaptive style modulation in a multi-scale NCA framework, the model achieves high-quality image generation with far fewer parameters than existing adversarial, variational, diffusion, and NCA baselines. Experiments on BloodMNIST and PathMNIST show competitive FID and KID scores, and the synthetic images preserve class-specific information, effectively supporting downstream multi-class classifier training.
By Anh Thi Luu, Nick Lemke, Anirban Mukhopadhyay
The paper introduces Flow-Based Distribution Matching (FBDM), a non‑adversarial method that learns self‑supervised representations by aligning images to explicit geometric references through spherical conditional velocity regression. By using an ETF‑inspired reference, FBDM allows more reference components than the flow dimension while maintaining geometric separation, and it incorporates an alignment loss to bring augmented views closer together. Experiments on datasets from CIFAR to ImageNet show that FBDM performs nearly as well as adversarial distribution‑matching methods, achieves a 1.48‑ to 1.83‑fold speedup, and offers a theoretical bound on downstream misclassification rates.
The paper argues that evaluating privacy‑enhancing technologies (PETs) solely through image classification is insufficient because classification remains robust to many geometric and local perturbations. It proposes a compute‑aware multi‑task protocol that uses lightweight proxy tasks to assess PETs across various transformations, revealing that PETs with similar classification accuracy can perform very differently on other vision tasks. The study demonstrates the necessity of broader evaluation metrics beyond classification to truly gauge PET effectiveness.
By Leon Ranke, Wolfgang H\"ubner, Ronny Hug, Michael Arens, J\"urgen Beyerer