arXiv:2608. 14657v1 Announce Type: new Abstract: Early identification of lung cancer risk is critical for timely intervention, yet existing prediction models are limited by their reliance on single data modalities and their inability to leverage structured clinical knowledge.
arXiv:2607. 09982v1 Announce Type: new Abstract: Electronic health record (EHR) data are inherently multimodal, and leveraging multiple modalities can improve predictive performance.
arXiv:2603.08459v2 Announce Type: replace Abstract: Safe predictions are a crucial requirement for integrating predictive models into clinical decision support systems. One approach to improving trus...
The paper presents a newly curated, multi-center, multi-modal, and longitudinal lung cancer dataset comprising 1,365 patients with whole-slide images, CT scans, PET scans, structured clinical data, transcriptomics, and follow-up information. The dataset features substantial, non-uniform missingness across modalities, making it ideal for evaluating robust multi-modal fusion strategies. Benchmarks on 12‑month overall survival, disease‑specific survival, and longitudinal hazard prediction demonstrate that integrating complementary modalities consistently outperforms uni-modal approaches, even under severe missing data.
arXiv:2607. 18270v1 Announce Type: new Abstract: While Electronic Health Records (EHRs) offer a wealth of clinical data, effectively augmenting a patient's records with heterogeneous external knowledge to predict the patient's clinical risk remains a significant challenge.
The paper introduces CFKD-AFN, a cross‑fidelity knowledge distillation and adaptive fusion network that uses abundant low‑fidelity simulation data to improve personalized treatment outcome predictions from scarce high‑fidelity trial data. The dual‑channel distillation module extracts complementary knowledge from the low‑fidelity model, while an attention‑guided fusion module adaptively integrates multi‑source information. Experiments on chronic obstructive pulmonary disease data demonstrate significant reductions in mean squared error (6.67%–74.55%) and mean absolute percentage error (1.43%–51.54%) compared to competing methods, and the framework can be extended to an interpretable variant for feature‑attribution analysis.
arXiv:2609.38924v1 Announce Type: new Abstract: Major adverse cardiovascular events (MACE) remain the leading cause of mortality worldwide. Opportunistic screening using routinely acquired clinical d...
arXiv:2607. 20453v1 Announce Type: cross Abstract: Large language models show promise for clinical prediction, but zero-shot performance on specialized tasks is limited by incomplete domain knowledge, especially for smaller locally deployable models.
arXiv:2606. 31171v1 Announce Type: new Abstract: Acquiring comprehensive cross-domain biomedical profiles is often costly and time-consuming, resulting in severe data scarcity in medical research.
The paper introduces an uncertainty‑aware clinical knowledge graph for chest X‑ray device reasoning, capturing device instances, tip estimates, placement assessments, provenance, report events, and temporal links as interconnected evidence. The graph builder processes 30,083 studies from 3,255 patients, producing 914,632 evidence nodes and 884,549 typed relationships, while preserving detailed uncertainty and provenance information for each predicted device. The authors also outline typed data contracts, uncertainty representations, abstention rules, report‑image grounding, and longitudinal query mechanisms, though the current analysis is post‑hoc descriptive and does not yet demonstrate clinical utility.
The paper introduces a Mixture of Multicenter Experts (MoME) framework that leverages diverse clinical strategies to reduce bias in medical AI without sharing data across institutions. MoME integrates specialized expertise from multiple centers, improving generalizability and adaptability of a multimodal target volume delineation model for prostate cancer radiotherapy. The model, trained with few-shot imaging and clinical notes, outperformed baselines, especially in high inter‑center variability or limited data scenarios, and allows local customization without cross‑institutional data exchange.
arXiv:2609.14072v1 Announce Type: new Abstract: Large Language Models (LLMs) have displayed impressive capabilities in handling tasks that require few demonstration examples, making them effective fe...
GRIN+ is a new machine unlearning framework that targets fast and precise data erasure in imbalanced medical datasets. It separates unlearning‑specific knowledge from general representations by analyzing gradient contributions of forget and retain sets, introduces a class‑adaptive influence scoring to counter gradient dominance, and uses a direction‑constrained update to protect essential clinical knowledge. Benchmarks on skin cancer, brain tumor, and breast ultrasound data show that GRIN+ balances privacy, efficiency, and utility, achieving high diagnostic accuracy and faster runtime than existing methods.