The paper introduces Generalist‑Specialist Mixture‑of‑Experts (GS‑MoE), a two‑branch architecture that combines a cross‑modal generalist model with modality‑specific specialists through domain‑constrained feature fusion. GS‑MoE improves detection of rare pathologies in multimodal medical imaging, achieving significant per‑class F1 gains and outperforming dense and specialist‑only MoE baselines while using about 53% fewer active parameters at inference. The study demonstrates that balancing cross‑modal shared representations with expert routing can enhance performance on low‑prevalence conditions.
By Johannes Kaiser, Florian Braunmiller, Daniel R\"uckert, Georgios Kaissis
arXiv:2409.16183v2 Announce Type: replace
Abstract: Radiology is a vital and complex component of modern clinical workflow and covers many tasks. Recently, vision-language (VL) foundation models in m...
By Xiaohong Liu, Guoxing Yang, Yulin Luo, Jiaji Mao, Xiang Zhang, Haibo Wang, Zhiyang He, Ming Gao, Shanghang Zhang, Jun Shen, Guangyu Wang
arXiv:2608. 16268v1 Announce Type: cross Abstract: Medical foundation models improve generalization when training AI models with limited labeled data, but remain confined to a single specialty, such as pathology or radiology, and to either sparse or dense outputs, such as classification or segmentation.
By J. Raphael Sch\"afer, Kai Geissler, Till Nicke, Chiara Tappermann, Karoline Heber, Eike Petersen, Habib Mergan, Lars Ole Schwen, Nick Weiss, Annika Gerken, Jan Hendrik Moltz, Tom Bisson, Isil Dogan O, Tim-Rasmus Kiehl, Norman Zerbe, Sefer Elezkurtaj, Robin S. Mayer, Nadine Flinner, Peter Wild, Isabel Dahm, Felix Peisen, Heinrich von Busch, Robert Grimm, Sebastian Arndt, Lisa Siegler, Matthias Stefan May, Antje Prasse, Natalia Artysh, Fabian Kiessling, Johannes Lotz
arXiv:2607. 09526v1 Announce Type: cross Abstract: Foundation models are reshaping computational pathology, yet their capabilities remain shaped by pretraining objectives, data sources, and spatial scales, fragmenting complementary expertise across separate backbones.
By Jiawen Li, Tian Guan, Huijuan Shi, Xitong Ling, Mingxi Fu, Anjia Han, Chao He, Yonghong He
arXiv:2603.02790v2 Announce Type: replace
Abstract: Foundation models are changing the way we develop medical artificial intelligence. By learning broadly generalizable features across diverse data m...
By Michelle Stegeman (and on behalf of the UNICORN consortium), Lena Philipp (and on behalf of the UNICORN consortium), Fennie van der Graaf (and on behalf of the UNICORN consortium), Marina D'Amato (and on behalf of the UNICORN consortium), Cl\'ement Grisi (and on behalf of the UNICORN consortium), Luc Builtjes (and on behalf of the UNICORN consortium), Joeran S. Bosma (and on behalf of the UNICORN consortium), Judith Lefkes (and on behalf of the UNICORN consortium), Rianne A. Weber (and on behalf of the UNICORN consortium), James A. Meakin (and on behalf of the UNICORN consortium), Thomas Koopman (and on behalf of the UNICORN consortium), Anne Mickan (and on behalf of the UNICORN consortium), Mathias Prokop (and on behalf of the UNICORN consortium), Ewoud J. Smit (and on behalf of the UNICORN consortium), Fr\'ed\'erique Meeuwsen (and on behalf of the UNICORN consortium), Geert Litjens (and on behalf of the UNICORN consortium), Jeroen van der Laak (and on behalf of the UNICORN consortium), Bram van Ginneken (and on behalf of the UNICORN consortium), Maarten de Rooij (and on behalf of the UNICORN consortium), Henkjan Huisman (and on behalf of the UNICORN consortium), Colin Jacobs (and on behalf of the UNICORN consortium), Francesco Ciompi (and on behalf of the UNICORN consortium), Alessa Hering (and on behalf of the UNICORN consortium)
nnFoundation introduces complementary convolutional and transformer-based 3D foundation models for radiology, trained on 2.1 million CT, MRI, and PET volumes from 125 datasets. The models are evaluated on 108 tasks—including segmentation, detection, classification, report generation, and image retrieval—under domain shift, low-data, and low-compute scenarios, consistently outperforming prior 3D foundation models and training from scratch. Performance varies by task type, with convolutional models excelling at spatially localized tasks and transformer models at global semantic reasoning, and dynamic alignment with dataset characteristics further enhances transferability.
By Constantin Ulrich Harsy, Tassilo Wald, Karol Gotkowski, Yannick Kirchhoff, Marcel Knopp, Maximilian Rokuss, Elisa Stegmeier, Philipp Schader, Dasha Trofimova, Raphael Stock, Kim-Celine Kahl, Stephen Schaumann, Selen Erkan, David Zimmerer, Stefan Denner, Moritz Langenberg, Sebastian Ziegler, Katharina Eckstein, Maximilian Fischer, Jonathan Suprijadi, B\'alint Kov\'acs, Benjamin Hamm, Anand Deshpande, Dimitrios Bounias, Nico Disch, Shuhan Xiao, Jessica K\"achele, Jan Sellner, Rajesh Baidya, Jeremias Traub, Lars Kr\"amer, Maximilian Zenk, Tim R\"adsch, Stefan Dvoretskii, Robin Peretzke, Jonathan Deissler, Alexandra Ertl, Partha Ghosh, Kris Dreher, Stefan Dinkelacker, Annika Reinke, Evangelia Christodoulou, Numan Saeed, Yoland Savriama, Santiago Estrada, David K\"ugler, Laura Alexandra Daza Barragan, Cristina Isabel Gonzalez Osorio, Jan Peeken, Michael Baumgartner, Marvin Teichmann, Guillaume Chabin, Matthias Kirchler, Valentin Koch, for the ALFA study, Markus Hohenhaus, Dimitri Koslov, Nina Decker, Mohammad Yaqub, Arnd Heuser, Martin Reuter, Julia A. Schnabel, Tobias Heimann, Florin Ghesu, Paul Brachmann, Claus P. Heu{\ss}el, Alexander Radbruch, Gianluca Brugnara, Aditya Rastogi, Martha Foltyn-Dumitru, Heinz-Peter Schlemmer, Ignaz Reicht, Julius C. Holzschuh, Michael Bach, Bram Stieltjes, Kai Schlamp, Lena Maier-Hein, Marco Nolden, Ralf Floca, Paul F. J\"ager, Philipp Vollmuth, Fabian Isensee, Klaus H. Maier-Hein
arXiv:2607. 14703v1 Announce Type: cross Abstract: Multiple instance learning (MIL) has become the main paradigm for whole-slide image (WSI) analysis in computational pathology.
By Mingxi Fu, Jiawen Li, Renao Yan, Jiali Hu, Qiehe Sun, Tian Guan, Yonghong He
arXiv:2509. 25594v2 Announce Type: replace-cross Abstract: Medical image segmentation is fundamental to clinical decision-making, yet existing models remain fragmented.
By Bangwei Guo, Yunhe Gao, Meng Ye, Difei Gu, Yang Zhou, Leon Axel, Dimitris Metaxas
arXiv:2607. 29462v1 Announce Type: cross Abstract: Adapting deep learning models to profound clinical heterogeneity typically relies on parameter-efficient fine-tuning (PEFT) to avoid the severe overfitting associated with full end-to-end network updates.
By Sebastian Doerrich, Daniel W\"urtinger, Francesco Di Salvo, Shyam Nandan Rai, Christian Ledig
arXiv:2606. 04922v1 Announce Type: cross Abstract: Current prompt-based and adapter-based tuning of vision-language models (VLMs) is attractive for medical imaging, where clinical data sensitivity favors frozen backbones and annotations are limited.
By Tran Dinh Tien, Zhiqiang Shen
The paper introduces a Mixture of Multicenter Experts (MoME) framework that leverages diverse clinical strategies to reduce bias in medical AI without sharing data across institutions. MoME integrates specialized expertise from multiple centers, improving generalizability and adaptability of a multimodal target volume delineation model for prostate cancer radiotherapy. The model, trained with few-shot imaging and clinical notes, outperformed baselines, especially in high inter‑center variability or limited data scenarios, and allows local customization without cross‑institutional data exchange.
By Yujin Oh, Sangjoon Park, Xiang Li, Pengfei Jin, Yi Wang, Jonathan Paly, Jason Efstathiou, Annie Chan, Jun Won Kim, Hwa Kyung Byun, Ik Jae Lee, Jaeho Cho, Chan Woo Wee, Peng Shu, Peilong Wang, Caiwen Jiang, Nathan Yu, Jason Holmes, Jong Chul Ye, Quanzheng Li, Wei Liu, Woong Sub Koom, Jin Sung Kim, Kyungsang Kim
arXiv:2506. 17337v5 Announce Type: replace-cross Abstract: Vision Language Models (VLMs) have shown promise in automating image diagnosis and interpretation in clinical settings.
By Yuan Zhong, Ruinan Jin, Qi Dou, Xiaoxiao Li