arXiv AI

An auditable conditional-strategy framework for open-ended decision-making in complex lung cancer

The article introduces MedGPT Clinical Explorer (MCE), a conditional‑strategy framework designed to aid complex lung cancer decision‑making by explicitly mapping patient conditions to pathway eligibility, deferral, and redirection. In a study with 250 physicians across 98 institutions, MCE‑assisted strategies achieved higher Admissible Pathway Attainment Scores (APAS) than unaided or retrieval‑reference approaches, indicating more comprehensive inclusion of clinically relevant content and coherent links among pathways, conditions, and actions. The authors suggest that MCE’s shared decision object could improve transparency of omissions and contingencies, warranting prospective evaluation of its impact on workflow and patient outcomes.

arXiv AI
Jul 10

Towards Precision Therapy in Hepatocellular Carcinoma: A Clinical-Reasoning LLM for Risk Stratification and Treatment Guidance

arXiv:2607. 08602v1 Announce Type: new Abstract: Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of cancer-related mortality.

By Peng Cui, Jitao Wang, Siyan Xue, Yao Huang, Haoming Xia, Dong Li, Dengxiang Liu, Weilin Wang, Liping Liu, Leida Zhang, Yunfu Cui, Tao Peng, Daolin Ji, Haitao Zhao, Wei Zhang, Xiaojuan Wang, Weijie Ma, Zongren Ding, Jinlong Li, Yuan Ding, Jiajing Zhao, Zhiyu Chen, Chengkun Yang, Ziyue Huang, Jiaqi Liu, Fusheng Liu, Yang Zhou, Xiaojuan Wang, Zhongquan Sun, Shiyun Bao, Xiaojun Wang, Ming Yang, Guangxin Li, Bin Shu, Yong Liao, Hongxuan Li, Yao Tang, Shizhong Yang, Yongyi Zeng, Yufeng Yuan, Yinpeng Dong, Jihui Hao, Jun Zhu, Jiahong Dong
Hugging Face Trending Papers
Aug 5

RESPClinBench: Benchmarking Multimodal Clinical Decision-Making and Longitudinal Disease Management in Respiratory Specialty Care

Background: Respiratory specialty care requires multimodal interpretation, longitudinal risk assessment, guideline-concordant intervention, and whole-course management, which are poorly represented by examination-oriented medical benchmarks. Objective: To develop RESPClinBench, a real-world scenario-based benchmark for respiratory clinical decision-making, and evaluate seven contemporary large language models across AECOPD-PIM and PNBIM.

arXiv Computer Vision
Sep 22

Performance vs Consistency: Evaluating a Foundation Model in Lung-RADS Screening

arXiv:2609.22281v1 Announce Type: new Abstract: Foundation models have recently demonstrated strong capabilities across a wide range of medical imaging tasks. However, their performance in structured...

By Benjamin Renoust, Pierre Baudot, Tiffany Foriel, Yousra Haddou, Charles Voyton, Pierre-Henri Siot, Ezequiel Geremia, Danny Francis, Jean-Christophe Brisset, Val\'erie Bourd\`es, Sylvain Bodard, Benoit Huet
arXiv AI
Sep 2

Towards AI-Assisted Clinical Trial Matching: Practical Considerations, Multicenter Evaluation, and Real-World Deployment

arXiv:2609.01202v1 Announce Type: cross Abstract: Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there i...

By Yin Fang, Qiao Jin, Shubo Tian, Lauren He, Maya Geer, Noor Naffakh, Ryan Huu-Tuan Nguyen, Zifeng Wang, Jimeng Sun, Charalampos S. Floudas, James L. Gulley, Kamilia Moalem, Catarina Martins Maia, Amanda Nottke, Juan W. Valle, Melinda Bachini, Lourdes Rocha-Nussbaum, Kari Ramage, Nikita Curry, Megan Barnes, Mandy Mansaray, Darlene Gabeau, Craig E. Grossman, Heath Skinner, Michael Burczynski, NIH-TrialBench Consortium, Zhiyong Lu
arXiv AI
Jul 14

Information-seeking failures of large language models in agentic clinical reasoning

arXiv:2607. 10275v1 Announce Type: new Abstract: Large language models achieve high scores on medical knowledge assessments, yet clinical reasoning requires actively deciding what to investigate under uncertainty.

By Krischan Braitsch, Laura K. Schmalbrock, Theresa Weltermann, Andrew F. Berdel, Isabella Miller, Kai Tran, Michael Heider, Sabrina Kraus, Florian Bassermann, Jacqueline Lammert, Sebastian Ziegelmayer, Marcus Makowski, Lisa C. Adams, Keno K. Bressem
arXiv AI
Aug 3

Reasoning in Real World Clinical Care: Why Large Language Models Are Not Yet Safe for Autonomous Clinical Decision Support

arXiv:2607. 28677v1 Announce Type: new Abstract: LLM now pass medical licensing examinations and, in curated cases, can rival physicians at diagnostic reasoning.

By Shayndhan Sivanathan, Shravan Nageswaran, Mehdi Zadem, Ryaan Sultan, Nicolas von Mallinckrodt, Max Solovyev, Alexey Matyushkin, Sumon Sadhu, Gabriele C DeLuca, Sanjeeva Jeyaretna, James Hillis, Manoj Ramachandran, Prakash Jayakumar
arXiv Computation and Language
Sep 25

Clinical Intent Extraction: A FHIR-Aligned Representation and the CIRCA Benchmark

The paper introduces Clinical Intent Extraction (CIE), a task that transforms fragmented clinical action annotations into complete structured records called Clinical Intent Representation (CIR). CIR decomposes each action into verb, type, coded target, timing, condition, request‑intent (aligned to HL7 FHIR) and modality, adding dimensions absent in prior datasets. By re‑expressing five heterogeneous corpora into CIR, the authors create CIRCA, a benchmark of 10,011 harmonized intents with human‑validated subsets, crosswalks, and a deterministic FHIR R4 mapper, and demonstrate that existing models perform poorly on the full task, highlighting the need for targeted development.

By Alexander Apartsin, Yehudit Aperstein