arXiv:2608.22062v1 Announce Type: new Abstract: Longitudinal clinical event-relation verification determines whether a patient record supports a specified relation among two or more clinical events....
arXiv:2508. 14817v2 Announce Type: replace-cross Abstract: Objective: To evaluate whether retrieval-augmented generation (RAG) can serve as an efficient alternative to long-context prompting for clinical reasoning over electronic health records (EHRs).
The study introduces an evidence-aware evaluation protocol for a retrieval‑augmented generation system focused on breast lesion management literature. Using an 18‑document corpus and 18 queries, the authors compared dense embeddings, BM25, and cross‑encoder reranking across various chunk sizes and overlaps, finding that a hybrid retriever with 384‑token chunks and 20% overlap achieved top‑three retrieval success for 17 of 18 queries and high recall and precision metrics. Expanding ground‑truth relevance annotations increased recognized evidence spans and accepted chunk targets, though retrieval rankings remained unchanged, underscoring the sensitivity of evaluation to annotation coverage.
arXiv:2608. 07796v1 Announce Type: new Abstract: Large language models perform strongly on medical knowledge benchmarks, but reliable clinical deployment requires agents to conduct defensible investigations over heterogeneous, longitudinal records: determining what evidence is needed, retrieving and reconciling structured and free-text data, grounding conclusions in verifiable evidence, and deferring cases that cannot be resolved reliably.
CT‑ΔBench is a new benchmark designed to evaluate vision‑language models on longitudinal 3D medical imaging difference reporting. It provides patient‑level split data, change‑aware metrics, and physician‑validated references to assess clinically meaningful interval changes between two CT scans. The paper also introduces DeltaMed, a baseline model that directly reasons over paired CT scans, and compares it to an indirect two‑stage approach that first generates single‑timepoint reports before differencing.
CliniCIRCA is a modular large‑language‑model framework that reconstructs longitudinal mental‑health patient journeys from raw electronic health record narratives. It temporally classifies clinical events in unstructured discharge summaries without explicit timestamps, producing 15,891 tagged events from 52 summaries and correcting 629 errors to create verified gold‑standard timelines. The framework then generates temporally grounded summaries, compressing each source by 1.52×, and scales to produce 1,000 silver‑standard timelines for training, showing that instruction tuning improves event extraction, temporal tagging, and summarization across models.
arXiv:2610.20512v1 Announce Type: new Abstract: Graph-based analysis of electronic health records (EHRs) yields disease-trajectory catalogs, but structural support does not establish semantic novelty...
The study evaluates an auditable patient‑timeline reconstruction system that tracks provenance, records revisions, and refuses to answer when evidence is missing. Using a synthetic corpus of 1,000 patients and 3,353 notes, two provenance‑aware Evidence Graph operators reduced graph size by 33–37% while preserving all answers across 6,813 query points; a fixed‑window baseline failed to answer over half of the points. The system’s evidence‑gating mechanisms (BioClinicalBERT and a zero‑shot LLM) responded appropriately to evidence‑unavailable controls, but performance varied on marker‑free controls, with BERT maintaining high accuracy but the LLM’s coverage dropping sharply. "whyItMatters":"The results demonstrate that provenance‑aware evidence graphs can significantly reduce data complexity while maintaining answer integrity, highlighting a practical approach to building auditable clinical NLP systems."
arXiv:2607. 18999v1 Announce Type: cross Abstract: Multi-turn medical consultation agents must decide what to ask, adapt to patient responses, and determine when the collected evidence is sufficient.
arXiv:2605.20292v2 Announce Type: replace Abstract: Numerical time-series models effectively process irregular electronic health record (EHR) trajectories, but do not expose which temporal patterns s...
arXiv:2609.18852v1 Announce Type: new Abstract: Longitudinal electronic health records (EHRs) capture years of patient history across notes, codes, labs, and procedures, and contain evidence needed t...
The paper introduces ICD-Deepresearch, a workflow that combines foundation models for electronic health records (EHR) and language models with medical search and ICD dictionaries to forecast future ICD codes for upcoming clinical encounters. It evaluates candidate code transitions by linking patient evidence, external clinical relations, and exact code semantics within a fixed top‑K budget, using SparseEHR for initial priors, GPT‑5 for complementary forecasts, and a final selection step that validates, deduplicates, and ranks candidates. The method achieves patient‑averaged precision/recall of 24.60/35.09% on MIMIC‑III and 25.14/48.32% on MIMIC‑IV, with physicians rating 51–68% of its retrieved documents as useful, outperforming standalone GPT‑5 web search and Medical Deep Research.