The paper introduces Colorist, a data‑augmentation method that uses classical statistical color matching to generate domain‑shifted medical images. By applying global mean‑standard‑deviation matching in RGB space, Colorist creates structurally intact variations without neural networks, outperforming deep generative models in fidelity and color alignment. Across multiple medical imaging datasets, it boosts balanced accuracy by up to 9% over state‑of‑the‑art domain‑generalization regularizers and 13% over no augmentation, while reducing computational cost and preserving anatomical structure.
By Sebastian Doerrich, Francesco Di Salvo, Shyam Nandan Rai, Marco Lents, Christian Ledig
arXiv:2607. 03253v1 Announce Type: cross Abstract: As hematoxylin & eosin (H&E) staining constitutes the primary entry point in routine diagnostic workflows, computer-aided diagnosis from whole-slide H&E images is of particular clinical relevance.
By Ivica Kopriva, Dario Sitnik, Arijana Pacic, Karolina Krstanac, Irena Veliki Dalic, Marijana Popovic Hadzija
InstEditSeg is a generative framework that treats medical segmentation as an instruction-driven image editing task. Instead of producing binary masks, it renders a color-coded overlay on the original image guided by textual instructions, leveraging latent diffusion models to align with natural image distributions and reduce domain gaps. The method incorporates a DINOv3 visual encoder and a multi-scale feature pyramid fused into the diffusion U‑Net, and uses a dual‑branch classifier‑free guidance strategy to lower inference cost, achieving competitive accuracy on polyp and skin lesion datasets while improving cross‑domain generalization and multi‑lesion segmentation.
By Ziquan Liu, Zhewei Zhu, Xuyang Shi
arXiv:2407. 13632v2 Announce Type: replace-cross Abstract: Deploying deep learning-based imaging tools across various clinical sites poses significant challenges due to inherent domain shifts and regulatory hurdles associated with site-specific fine-tuning.
By Abhijeet Parida, Antonia Alomar, Zhifan Jiang, Pooneh Roshanitabrizi, Austin Tapp, Maria Ledesma-Carbayo, Ziyue Xu, Syed Muhammed Anwar, Marius George Linguraru, Holger R. Roth
arXiv:2609.00984v1 Announce Type: cross
Abstract: Virtual staining aims to computationally generate target-stained histopathological images while reducing the cost and time associated with convention...
By Baoshun Wang, Weiping Lin, Linwu Wang, Yihuang Hu, Baptiste Magnier, Liansheng Wang
arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.
By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
The paper presents a 3D foundation model for light sheet fluorescence microscopy (LSM) that is pretrained on a large curated set of 3D images from various organisms, stains, and imaging protocols. By jointly optimizing for masked reconstruction and image‑text alignment, the model learns transferable volumetric representations that dramatically reduce the need for annotated data. The pretrained backbone enables efficient few‑shot adaptation to downstream tasks such as segmentation, classification, and deblurring, consistently outperforming baselines according to standard metrics and expert evaluation.
By Adina Scheinfeld, Haotan Zhang, Shang Mu, Rudolf L. M. van Herten, Lucas Stoffl, Ali Erturk, Zhuhao Wu, Johannes C. Paetzold
arXiv:2609.36429v1 Announce Type: new
Abstract: Predicting gene expression from H&E-stained histology images offers a scalable alternative to costly spatial transcriptomics, yet most existing methods...
By Zijun Gao, Chunbin Gu, Jinxi Xiang, Xiangde Luo, Pheng-Ann Heng
arXiv:2606. 24430v1 Announce Type: cross Abstract: Training of neural networks for histopathology classification tasks typically relies on data encoding into latent space, which reduces complexity and improves performance.
By Christian Z\"ollner (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital), Mozzam Motiwala (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital), Aysel Ahadova (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital), Gerrit Anders (Leibniz Institut f\"ur Wissensmedien), Robert H\"uneburg (National Center for Hereditary Tumor Syndromes University Hospital Bonn, Department of Internal Medicine I University Hospital Bonn), Jacob Nattermann (National Center for Hereditary Tumor Syndromes University Hospital Bonn, Department of Internal Medicine I University Hospital Bonn), Matthias Kloor (Department of Applied Tumor Biology Institute of Pathology Heidelberg University Hospital)
arXiv:2606. 07633v1 Announce Type: cross Abstract: Accurate classification of nuclei subtypes in histopathology images is critical for downstream tasks including tumor grading, immune infiltrate quantification, and prognosis prediction.
By Spoorthi M, Suja Palaniswamy
arXiv:2606. 16991v1 Announce Type: cross Abstract: Multiphasic contrast-enhanced CT (CECT) is widely used for abdominal lesion characterization, yet it carries inherent risks of contrast-induced nephropathy, escalates acquisition burden, and heavily contributes to radiologist workload.
By Mariam Elbakry, Aliaa Sayed Sheha, Salma Hassan Tantawy, Aya Yassin, Concetto Spampinato, Karim Lekadir, Xiaomeng Li, Marawan Elbatel
arXiv:2603. 13377v2 Announce Type: replace-cross Abstract: Representation learning has driven major advances in natural image analysis by enabling models to acquire high-level semantic features.
By Ivan Svatko, Maxime Sanchez, Ihab Bendidi, Gilles Cottrell, Auguste Genovesio