arXiv AI By Baoshun Wang, Weiping Lin, Linwu Wang, Yihuang Hu, Baptiste Magnier, Liansheng Wang

Semi-Supervised Virtual Staining via Morphology Preservation and Histopathological Realism Constraints

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arXiv Computer Vision
Aug 26

Towards Reliable AI-Based Histological Staining: A Systematic Study of Scaling and Uncertainty in Unpaired Generative Models

The paper presents a systematic evaluation of six unsupervised image‑to‑image generative models for virtual Sirius Red staining of mouse liver tissue from routine H&E slides. It benchmarks these models across 54 scaling configurations on a newly released paired H&E‑to‑SR dataset, assessing perceptual, distributional, and task‑specific performance, and further trains the best models into deep ensembles to quantify epistemic uncertainty. The study finds that GAN‑based and diffusion‑based methods differ markedly across these metrics, indicating that reliable virtual staining requires reporting and selecting on all three axes simultaneously.

By Qasim Siddiqui, Adrian Friebel, Maiju Myllys, Zaynab Hobloss, Daniela Gonzalez, Ahmed Ghallab, Stefan Hoehme
arXiv AI
Sep 2

StainPresetNet: Stain Preset Network for Fast Multi-to-Multi Stain Normalization

StainPresetNet is a new framework for stain normalization that combines structural preservation with dataset-level color mapping while remaining computationally efficient. It uses pixel-wise normalization guided by preset reference images, allowing multi-directional adaptability without retraining. Experiments on cytopathology and histopathology datasets show that it outperforms conventional methods in color mapping accuracy, improves classifier generalization, and cuts computational overhead by 90% compared to existing deep learning approaches.

By Hongtao Kang, Die Luo, Li Chen, Jing Cai, Junbo Hu, Xiuli Liu, Shenghua Cheng
arXiv AI
Jul 7

Semantic Segmentation-Driven Image-Level Diagnosis of Liver Cancers in Hematoxylin and Eosin Histopathology Images

arXiv:2607. 03253v1 Announce Type: cross Abstract: As hematoxylin & eosin (H&E) staining constitutes the primary entry point in routine diagnostic workflows, computer-aided diagnosis from whole-slide H&E images is of particular clinical relevance.

By Ivica Kopriva, Dario Sitnik, Arijana Pacic, Karolina Krstanac, Irena Veliki Dalic, Marijana Popovic Hadzija
arXiv AI
Jun 8

DaX: Learning General Pathology Representations Across Scales

arXiv:2606. 06983v1 Announce Type: cross Abstract: Computational pathology requires visual representations that transfer across diverse clinical endpoints and remain robust to variation in magnification, staining, scanner type, slide preparation, and input resolution.

By Bokai Zhao, Yiyang Zhang, Long Bai, Tai Ma, Hanqing Chao, Minfeng Xu
arXiv Machine Learning
Aug 5

Assessment of Conditional Diffusion Model for Synthetic Histopathology Image Generation

arXiv:2608. 03990v1 Announce Type: new Abstract: Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications.

By Seyed Kahaki, Shijie Li, Weijie Chen, Nicholas Petrick