arXiv AI

GraphMed-LT: Patient-Specific Graph Memory with Latent Clinical Thought Refinement for Multi-Turn Medical Conversations

arXiv AI
Sep 15

ClinAgent: A ReAct-Based Agent for Conversational Access to Clinical Trial Information

ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.

By Antonino Vaccarella, Riccardo Cantini, Domenico Talia, Paolo Trunfio, Marianna Talia, Rosamaria Lappano, Marcello Maggiolini
arXiv Computation and Language
Sep 28

PIA: A Personal Intelligence Agent Turning Health Conversations into Records and Records into Understanding

PIA is a personal intelligence agent that works alongside a consumer health agent to convert health conversations into structured clinical records and to transform those records into a synthesized understanding of the user. It uses a memory system with four controls—extraction, memory, retrieval, and understanding—each supported by a health module that includes a schema, medical alias dictionary, knowledge graph, and temporal rules. The agent demonstrates that deeper memory injection—from simple recall to a health snapshot to a causal trajectory—yields progressively richer answers, while also revealing challenges such as missing self‑reported data, the influence of question phrasing, and the presence of structural noise in causal links.

By Jeonghun Yoon, Dongchan Kim, Hongyeon Yu, Young-Bum Kim, Jaegul Choo
arXiv AI
Jun 9

From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAG

arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.

By Wenhao Wu, Zhentao Tang, Yafu Li, Shixiong Kai, Mingxuan Yuan, Zhenhong Sun, Chunlin Chen, Zhi Wang
arXiv Computation and Language
Sep 22

Knowledge Graph-Augmented Ambient AI for Clinical Note Generation

arXiv:2609.22239v1 Announce Type: new Abstract: Ambient AI is increasingly adopted in healthcare to automatically generate clinical notes from patient-clinician conversations, with the potential to s...

By Jakir Hossain, Yi-Fei Zhao, Hongjian Wang, Minmei Shih, Katie Leigh Mullen, Ahmad P. Tafti, Leming Zhou, Manoj Purohit, William Hogan, Jay Zeng, Elizabeth Skidmore, Yanshan Wang
arXiv AI
Oct 1

Personalized State-Transition-Aware Memory for Clinical Agents

The paper introduces STAM, a state‑transition‑aware memory framework for large language model agents that process clinical records. STAM records changes in a patient’s state as new entries arrive, using semantic retrieval and typed clinical relations to separate current information (Active) from superseded or resolved information (History). During retrieval, a query‑dependent gate selects the appropriate historical memory, enabling accurate question answering and state‑maintenance diagnostics across four longitudinal clinical benchmarks.

By Maryam Haghifam, Zahra Rajabi, Yizhou Sun, Carlos Morato
arXiv AI
Sep 7

REFINE: LLM Refinement over Budgeted Text-Attributed Graphs for Personalized Medical Concept Representation

REFINE is a framework that refines medical concept representations by creating patient‑specific temporal graphs from a global text‑attributed knowledge graph. It uses a reinforcement learning policy to allocate a personalized graph expansion budget for each observed code, then processes the resulting graph with a heterogeneous GNN and a frozen LLM that refines representations via graph‑aware soft prompts. Experiments on MIMIC‑III and MIMIC‑IV demonstrate that REFINE consistently improves various EHR prediction backbones, surpasses strong baselines, and shows robust gains across ablation studies, KG selection, and data insufficiency scenarios.

By Mohsen Nayebi Kerdabadi, Arya Hadizadeh Moghaddam, Dongjie Wang, Zijun Yao