VirtualTrialHarness: Coordinating Agentic Operationalization of Virtual Trial Protocols Across Complex Clinical Schemas

VirtualTrialHarness (VTHarness) is an agent framework designed to streamline the operationalization of virtual trial protocols by selecting reusable procedural skills for each workflow stage and using explicit contracts to ensure consistent study decisions. It introduces VTBenchmark for evaluating source selection and cohort construction, achieving 95.1% workflow success after requirement clarification versus 60.4% with a standard procedural corpus. The framework demonstrated improved source recovery across language models, increased overlap with analyst code in Mayo Clinic cases, and enabled reference‑matched cohort execution across multiple MIMIC‑IV tasks, supporting investigator review within the Mayo Clinic Virtual Trials Program.

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• llms
• agents