arXiv:2606. 09671v1 Announce Type: cross Abstract: Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring.
By Yinyu Huang, Yilin Zhang, Sofia Michopoulou, Christopher Kipps, Rahman Attar
arXiv:2607. 00431v1 Announce Type: new Abstract: Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost.
By Md Rakibul Haque, Shireen Elhabian, Warren Woodrich Pettine
Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring. Existing machine learning approaches have improved AD prediction using multimodal data, yet often focus on static classification or cohort-level risk estimation, providing limited support for subject-specific modelling and uncertainty-aware reasoning.
arXiv:2606. 27334v1 Announce Type: new Abstract: Digital twins have emerged as a promising paradigm for personalized healthcare, enabling modeling of individual behavior and health trajectories.
By Mohammad Mehdi Hosseini, Mohammad H. Mahoor, Hiroko H. Dodge
arXiv:2301. 07210v5 Announce Type: replace-cross Abstract: Digital twins are simulation-based models designed to predict how a real-world process will evolve in response to interventions.
By Rob Cornish, Muhammad Faaiz Taufiq, Arnaud Doucet, Chris Holmes
The paper presents a reliability‑aware benchmarking framework for short‑term glycemic risk prediction, using 5,503,441 prediction anchors from 736 type‑1 diabetes patients. Three neural models—a Hybrid LSTM‑Transformer, a Multimodal Digital Twin, and a State‑Updating Digital Twin—were evaluated on 30‑, 60‑, and 120‑minute horizons for hypoglycemia and hyperglycemia, with identical patient‑level validation. While no significant differences in predictive accuracy were found, the models displayed distinct reliability traits: the Multimodal Digital Twin had the lowest Brier score, the State‑Updating Digital Twin the lowest expected calibration error, and the Hybrid LSTM‑Transformer the strongest explanation faithfulness.
By Pir Bakhsh Khokhar, Carmine Gravino, Fabio Palomba