arXiv Machine Learning By Ashish Anton Abraham, Gopi Krishnan R, Aiswarya Anil Nair, Ajo Babu George, Kunal Agarwal

Hybrid SEIR Temporal Fusion Transformer Framework with SHAP Analysis for Interpretable Pandemic Forecasting

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arXiv AI
Oct 16

Prospective multi-pathogen disease forecasting using autonomous LLM-guided tree search

The paper introduces Empirical Research Assistance (ERA), an autonomous system that employs Large Language Model‑guided tree search to create, evaluate, and refine executable forecasting software for infectious diseases. In a real‑time evaluation during the 2025‑26 U.S. respiratory season, ERA produced diverse models for influenza, COVID‑19, and RSV, and an ensemble of these models outperformed the CDC’s gold‑standard forecast ensembles across all three pathogens. ERA also demonstrated robustness in data‑scarce RSV scenarios and showed that higher‑tier language models and specific optimization metrics can improve forecast accuracy.

By Sarah Martinson, Michael P. Brenner, Martyna Plomecka, Brian P. Williams, Nicholas G. Reich, Zahra Shamsi