arXiv Machine Learning By Yiqi Su, Ray Lee, Jiaming Cui, Naren Ramakrishnan

How (Not) to Hybridize Neural and Mechanistic Models for Epidemiological Forecasting

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arXiv:2602. 06323v2 Announce Type: replace Abstract: Epidemiological forecasting from surveillance data is a hard problem and hybridizing mechanistic compartmental models with neural models is a natural direction.

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arXiv Machine Learning
Sep 15

Generative diffusion models for spatiotemporal influenza forecasting

The paper introduces Influpaint, a denoising diffusion probabilistic model adapted for forecasting influenza incidence. By representing influenza seasons as spatiotemporal images and training on a hybrid dataset of surveillance and simulated trajectories, the model learns a rich distribution of disease dynamics and performs forecasting as a conditional generation task. In retrospective and real‑time evaluations, Influpaint produces realistic, diverse epidemic trajectories and achieves forecast accuracy competitive with leading ensemble methods, especially when trained with 30% surveillance and 70% simulated data.

By Joseph Lemaitre, Justin Lessler