EXPOSE: Explainable and Domain-Robust Embeddings from Pathology Vision Foundation Models using Sparse Autoencoders
Read the original on arXiv Machine Learning →EXPOSE is a framework that applies Sparse Autoencoders to Vision Foundation Model embeddings in computational pathology, aiming to separate biological signals from domain‑specific noise. By training a sparse representation of VFM features and using a linear classifier to flag domain‑specific latent dimensions, the method masks these components before downstream relapse prediction, avoiding the need to retrain the backbone model. Experiments on a large prostate cancer dataset demonstrate that removing domain‑specific features improves cross‑domain performance and raises the Domain Robustness Index (DoRI).
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