arXiv Computer Vision September 23, 2026 By Shengjie Zhang, Jinglin Zhang, Zhuangzhuang Jiang, Ziqi Yu, Yipin Zhang, Qi Zhang, Xiang Chen, Haibo Yang, Fei Gao, Longbiao Cui, Yuan Zhou, Xiao-Yong Zhang, Alzheimer's Disease Neuroimaging Initiative

Decoupling Disease, Covariates, and Individual Variability: A Unified Disentanglement Framework for Medical Image Classification

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The paper introduces MedIDL, a Medical Imaging Disentanglement Learning framework that separates disease-related features from confounding covariates and individual variability in medical images. It achieves this by projecting image features into three orthogonal latent spaces—disease classification, covariate alignment, and a Gaussian head for individual variation—using specialized disentanglement heads. Across seven diverse imaging datasets, MedIDL surpasses state‑of‑the‑art supervised and self‑supervised methods in classification accuracy, and its latent representations and gradient‑based visualizations align with known clinical patterns.

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