The paper introduces Latent Drift, a generative forecasting framework that predicts slow-evolving neurodegenerative disease progression by learning changes in a compressed semantic representation rather than full-resolution anatomy. It addresses two failure modes—identity collapse and continuous interpolation trap—by removing pixel-level identity from the prediction target and applying Finite Scalar Quantization to suppress high-frequency nuisance fluctuations. Experiments on longitudinal 3D brain MRI demonstrate that Latent Drift outperforms diffusion and autoregressive transformer baselines in both generative fidelity and clinically relevant metrics.
By Yuxiang Feng, Juncheng Wang, Chao Xu, Wenlong Hou, Huihan Wang, Yijie Qian, Yang Liu, Baigui Sun, Yong Liu, Shujun Wang
The paper introduces a reverse spatio‑temporal disease progression model that reconstructs unobserved healthier anatomy from later diseased scans. It employs a two‑stage architecture: a frozen 3D vector‑quantised autoencoder creates a discrete latent space, and a Neural ODE learns continuous‑time dynamics, with a recurrent encoder initializing the latent state from reverse‑ordered observations. Experiments on a synthetic Morpho‑MNIST benchmark and longitudinal Alzheimer’s MRIs show the model can recover unseen prior states and outperform baseline methods in predicting healthy trajectories.
By Ulugbek Shernazarov, Moucheng Xu, Inomjon Ramatov
arXiv:2604. 22700v2 Announce Type: replace Abstract: Modeling and predicting neurodegenerative disease progression from medical images remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning.
By Nivetha Jayakumar, Swakshar Deb, Bahram Jafrasteh, Qingyu Zhao, Miaomiao Zhang
NOAH is a generative transformer that models the entire multimodal patient journey by integrating bidirectional time and a variational latent space to capture continuous, stochastic clinical trajectories. Trained on over 559 million events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual simulations, yielding strong predictive performance across 15 ICD chapters, 29 comorbidities, and time‑to‑event outcomes.
arXiv:2512.23441v2 Announce Type: replace
Abstract: Temporally aware image representations are crucial for capturing disease progression in 3D volumes of longitudinal medical datasets. However, recen...
By Taha Emre, Arunava Chakravarty, Thomas Pinetz, Dmitrii Lachinov, Martin J. Menten, Hendrik Scholl, Sobha Sivaprasad, Daniel Rueckert, Andrew Lotery, Stefan Sacu, Ursula Schmidt-Erfurth, Hrvoje Bogunovi\'c
The paper proposes a method for adapting pretrained latent spaces without retraining the encoder or decoder by inserting an invertible bi‑Lipschitz adapter that aligns the latent coordinates to a semantic teacher. This offline alignment preserves the compression and reconstruction properties of the original autoencoder while improving semantic organization. Experiments on two medical imaging datasets show that constrained adaptation enhances feature metrics, seed stability, and counterfactual edit strength, and remains competitive on downstream classification tasks.
By Felix N\"utzel, Mischa Dombrowski, Luca Hagen, Bernhard Kainz