arXiv Computer Vision
Sep 23

Decoupling Disease, Covariates, and Individual Variability: A Unified Disentanglement Framework for Medical Image Classification

The paper introduces MedIDL, a Medical Imaging Disentanglement Learning framework that separates disease-related features from confounding covariates and individual variability in medical images. It achieves this by projecting image features into three orthogonal latent spaces—disease classification, covariate alignment, and a Gaussian head for individual variation—using specialized disentanglement heads. Across seven diverse imaging datasets, MedIDL surpasses state‑of‑the‑art supervised and self‑supervised methods in classification accuracy, and its latent representations and gradient‑based visualizations align with known clinical patterns.

By Shengjie Zhang, Jinglin Zhang, Zhuangzhuang Jiang, Ziqi Yu, Yipin Zhang, Qi Zhang, Xiang Chen, Haibo Yang, Fei Gao, Longbiao Cui, Yuan Zhou, Xiao-Yong Zhang, Alzheimer's Disease Neuroimaging Initiative
arXiv Machine Learning
Sep 15

Representing Clinical Conditions on Vital Signs from Healthy Individuals using Latent Modeling

The paper introduces a deep generative model using conditional variational autoencoders to augment vital sign data from healthy individuals so that it mimics patterns of specific clinical conditions. Trained on a publicly available ICU dataset, the model learns the underlying dynamics of ICU data and reshapes healthy data to align with target clinical labels. A proposed distance metric demonstrates that the generated samples are more aligned with intended clinical labels than baseline methods.

By Rafael Pina, Varuna De Silva, Mindula Illeperuma