The study presents an interpretable AI framework for glaucoma screening using low-cost handheld retinal cameras in a West African population. Trained on 681 participants, the system achieved high performance across vessel segmentation, cup/disc segmentation, and optic nerve head feature detection, with classification AUCs of 0.85 for the handheld device and 0.93 for a tabletop camera. The model provides confidence scores and visual explanations to aid clinical interpretation.
By Charis Y. N. Chiang, Tarela Sarimiye, Adeyinka Ashaye, Martin Buist, Michael A. Hauser, Olusola Olawoye, Micha\"el J. A. Girard
The study developed a Vision Transformer-based deep learning model with uncertainty estimation to detect glaucoma from colour fundus photographs across multi‑ethnic populations, including those with high myopia. Using 56,483 images for training, the model achieved an internal AUROC of 98.7% and maintained high performance (AUROC 86.4–99.6%) on 16 external datasets from eight countries. In high‑myopia eyes, the model outperformed ophthalmologists and matched specialists when full clinical data were available.
By Raghavan Lavanya, Yangqin Feng, Ten Cheer Quek, Quan V. Hoang, Linda Yi-Chieh Poon, Jost B. Jonas, Ya Xing Wang, Vinay Nangia, Jin Wook Jeoung, Sehie Park, SoYeon Kim, Benjamin Y Xu, Sreenidhi Iyengar Munimadugu, Paul Mitchell, Gerald Liew, Yanin Suwan, Jirayu Hong-amata, Sahil Thakur, Monisha E Nongipur, Tina Wong, Rahat Husain, Ng Si Rui, Yamon Syn, Phey Feng Lo, Nicholas Tan Yi Qiang, Shaista Hussain, Xiaofeng Lei, Zhi Da Soh, Marco Yu, Haslina Hamzah, Zizhou Wang, Yan Wang, Liangli Zhen, Xinxing Xu, Tien-Yin Wong, Tin Aung, Rachel S Chong, Yong Liu, Ching-Yu Cheng
Background: Artificial intelligence (AI)-based glaucoma detection from colour fundus photographs (CFP) offers scalable screening, but performance may decline on external datasets because of difference...
OptiModNet is a lightweight UNet‑Transformer hybrid designed for optic disc and cup segmentation. It incorporates grouped‑query and channel attention across multiple stages, along with an Aggregated Pyramid Loss to improve gradient flow and structural consistency. Evaluated on the REFUGE2 dataset, it surpasses existing methods by over 2.5 % while using only 3.73 GFLOPs and 1.93 M parameters.
By Soumili Ghosh, Debapriya Roy, Aryan Das, Bikash Santra
arXiv:2607. 04673v1 Announce Type: cross Abstract: Glaucoma is a leading cause of irreversible blindness worldwide, yet most automated diagnosis systems rely on opaque deep-learning models that offer little clinical interpretability.
By Cheng Huang, Jia Zhang, Yi Jiang, Yang Liu, Karanjit Kooner, Yadi Liu, Tsengdar Lee, Yang Xie, Wenqi Shi, Guanghua Xiao
arXiv:2607. 19864v1 Announce Type: cross Abstract: Diabetic retinopathy is a leading cause of preventable blindness; its early lesions are small, low contrast, and easily missed in manual screening.
By Z\"ubeyr \"Ozeren, Tansel Uyar