arXiv AI

Aletheia: An Offline-First Clinical Decision Support System for Differential Diagnosis in Low-Resource Healthcare Settings

arXiv:2607. 24814v1 Announce Type: new Abstract: Access to specialist clinical expertise remains severely limited across sub-Saharan Africa, where physician-to-patient ratios can fall below 1:25,000 in rural settings.

arXiv AI
Aug 18

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

arXiv:2505. 14107v5 Announce Type: replace-cross Abstract: The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios.

By Yakun Zhu, Zhongzhen Huang, Linjie Mu, Yutong Huang, Wei Nie, Jiaji Liu, Shaoting Zhang, Pengfei Liu, Xiaofan Zhang
arXiv AI
Jun 24

A specialized reasoning large language model for accelerating rare disease diagnosis: a randomized AI physician assistance trial

arXiv:2606. 24510v1 Announce Type: new Abstract: Rare diseases affect millions of individuals worldwide, yet timely diagnosis remains a major public health challenge due to scarcity of specialized clinical expertise.

By Haichao Chen, Songchi Zhou, Zhengyun Zhao, Shikai Hu, Xianghong Jin, Hongwei Ji, Li He, Shuli Li, Yiming Qin, Xin Tan, Runfeng Shi, Yih Chung Tham, Jiaye Zhu, Ye Li, Ye Jin, Longhao Cao, Dawei Li, Honghan Wu, Hongqiu Gu, Guanqiao Li, Tudor Groza, Chunying Li, Dian Zeng, Weihong Yu, Gareth Baynam, Saumya Shekhar Jamuar, Min Shen, Shuyang Zhang, Bin Sheng, Sheng Yu, Tien Yin Wong
arXiv AI
Jun 17

RubricsTree: Scalable and Evolving Open-Ended Evaluation of Personal Health Agents across Health Memory and Medical Skills

arXiv:2606. 18203v1 Announce Type: cross Abstract: The LLM-empowered personal health agents with user health (sensor) metrics have offered a promising pathway to alleviate global disparities in healthcare access.

By Weizhi Zhang, Zechen Li, Hamid Palangi, Ben Graef, A. Ali Heydari, Simon A. Lee, Salman Rahman, Ray Luo, Zeinab Esmaeilpour, Erik Schenck, Chloe Zhang, Yamin Li, Menglian Zhou, Philip S. Yu, Daniel McDuff, Lindsey Sunden, Mark Malhotra, Shwetak Patel, Ahmed A. Metwally
arXiv Machine Learning
Aug 14

A Cloud-Edge System for Multimodal Clinical Screening in Resource-Constrained Rural Settings

arXiv:2608. 12745v1 Announce Type: new Abstract: Medical AI has demonstrated specialist-level diagnostic accuracy, yet these capabilities remain largely inaccessible in resource-constrained rural settings where bandwidth is scarce, compute is limited, and clinical decision-making requires integrating heterogeneous modalities.

By Hei Ting (Una), Chan, Chenwei Wu, Xueshen Liu, Zesen Zhao, Boyuan Zheng, Luis Filipe Nakayama, Michael G. Morley, Liyue Shen, Jiasi Chen, Z. Morley Mao
arXiv AI
Jul 28

RareLens: Towards End-to-End Rare Disease Care via Aligning Divergent Large Language Model Reasoning

arXiv:2607. 23290v1 Announce Type: new Abstract: Rare diseases collectively affect an estimated 3.

By Xi Chen, Hongru Zhou, Shiyu Feng, Hanyu Zhou, Huahui Yi, Rongsheng Wang, Tiancheng He, Kun Wang, Pingping Liu, Qiankun Li, Sicheng Lin, Huiying Ou, Xiaohong Zheng, Tianying Zang, Zhuohang Wu, Leheng Jiang, Kexin Cao, Wenhan Zhang, ChengYi Li, Zhiyang Wang, Songlin Li, Benyou Wang, Ningbei Yin, Shaoting Zhang, Weili Fu, Jian Li, Kang Li
Hugging Face Trending Papers
Aug 13

A Cloud-Edge System for Multimodal Clinical Screening in Resource-Constrained Rural Settings

Medical AI has demonstrated specialist-level diagnostic accuracy, yet these capabilities remain largely inaccessible in resource-constrained rural settings where bandwidth is scarce, compute is limited, and clinical decision-making requires integrating heterogeneous modalities. We introduce a cloud--edge collaborative architecture that addresses these constraints: lightweight, domain-specific models on the edge transform raw medical data into compact structured outputs, while a cloud LLM synthesizes these outputs into clinical summaries.

arXiv AI
Jul 10

A safety-oriented hypothetico-deductive framework for AI-assisted differential diagnosis

arXiv:2607. 08038v1 Announce Type: new Abstract: Diagnostic error is a major threat to patient safety, yet current large language model (LLM) systems often treat diagnosis as a one-shot prediction task, lacking safeguards against missed high-risk alternatives or rigorous verification of their reasoning.

By Fan Ma, Mauro Giuffr\`e, Donald Wright, Kent McCann, Mark Iscoe, Lingfei Qian, Mingyang Jiang, Chi Wing Ng, Na Hong, Huan He, Cathy Shyr, Qingyu Chen, Lee Schwamm, Lucila Ohno-Machado, Hua Xu
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv Computation and Language
Sep 4

Gaokerena: A Small Persian Medical Language Model Family

Gaokerena is a family of compact Persian medical language models designed for consumer‑grade hardware. The first variant, Gaokerena‑V, was trained on a 90‑million‑token Persian medical corpus and 20,000 physician Q&A pairs, raising a translated medical MMLU benchmark score from 46.28% to 49.31%. A second variant, Gaokerena‑R, adds a Chain‑of‑Thought approach and two Reinforcement Learning with AI Feedback frameworks, achieving a higher benchmark score of 52.98% while also providing uncertainty estimates based on internal hidden states.

By Mehrdad Ghassabi, Hamidreza Baradaran Kashani, Pedram Rostami, Sadra Hakim, Zahra Kazemi, Amirhossein Poursina, Milad Tavakoli, Audrina Ebrahimi