arXiv:2606. 17441v1 Announce Type: cross Abstract: Simulating realistic patient interactions is a key requirement to testing clinical applications of LLMs at scale without time-consuming and expensive user studies.
By Moritz Schlager, Friederike Jungmann, Samuel Schmidgall, Philipp Raffler, Franziska Hartl, Eva Wende, Paula Ro{\ss}m\"uller, Conrad Ketzer, Avinatan Hassidim, Dale R. Webster, Yossi Matias, Yun Liu, Daniel Rueckert, Mike Schaekermann, Paul Hager
arXiv:2602.01995v2 Announce Type: replace
Abstract: Conversational diagnosis requires multi-turn history-taking, where an agent asks clarifying questions to refine differential diagnoses under incomp...
By Jeongmoon Won, Seungwon Kook, Yohan Jo
The study introduces a scaffolding-oriented multi-agent Large Language Model (LLM) AI Standardized Patient (AI-SP) platform designed to train medical students in patient interviews. In a randomized controlled trial with 100 students, the multi-agent system—comprising a patient agent, a Socratic tutor agent, and a turn-level evaluator—did not improve diagnostic accuracy but significantly enhanced overall OSCE scores, especially in communication, empathy, and history-taking. The authors also release a richly annotated dataset to support further research in AI-supported clinical reasoning training.
By Luming Yang, Haoxian Liu, Siqing Li, Rong Jia, Yue Xiao, Guanhua Chen, Li Lu
arXiv:2606. 17474v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly considered for use in clinical consultation tasks, yet most medical evaluations remain static, single-turn, or narrowly outcome-based, limiting their ability to reflect the sequential, uncertain, and interactive nature of real-world care.
By Jiahui Niu, Huizi Yu, Wenkong Wang, Guangxin Dai, Jingxian He, Xiang Li, Zhiying Liang, Xinxin Lin, Kent CY So, Bryan YP Yan, Yun Kwok Wing, Yanqiu Xing, Xin Ma, Lizhou Fan
arXiv:2606. 15735v1 Announce Type: cross Abstract: Discharge summaries are crucial clinical documents containing the context of a patient's overall hospital stay, and are routinely reviewed by medical experts for patient readmission, ongoing care, and diagnostic decision-making.
By Jiyoun Kim, Muhan Yeo, Eunhye Jang, Jeewon Yang, Hangyul Yoon, Su Ji Lee, Hee Jo Han, Hee-Jae Jung, Doyun Kwon, Jun young Lee, Jaehun Lee, Jung-Oh Lee, Sunjun Kweon, Jong Hak Moon, Daseul Kim, Minjae Cho, Edward Choi
arXiv:2609.38480v1 Announce Type: cross
Abstract: Most clinical benchmarks evaluate language models (LMs) on diagnosis using complete case descriptions. In clinical practice, however, patients presen...
By Xueting Fang, Zehui Li, Yang Yang, Camilla Giovino, Shubh K. Patel, Shailly Prajapati, Vallijah Subasri, Caihua Shan
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.
By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
The paper investigates how medical large language models (LLMs) may exhibit narrative anchoring bias when presented with the same clinical case in different patient voices. Using the NarrativeShield SDoH MedQA dataset, the authors evaluate three Qwen2.5 instruction‑tuned LLMs (1.5B, 3B, 7B) on 300 clinical cases, reporting metrics such as persona‑level accuracy, counterfactual consistency, correct consistency, and narrative sensitivity error. The 7B model achieves the highest accuracy (56.33 %) and correct consistency (40.33 %), yet narrative sensitivity errors remain substantial (31.67 %).
By Ahnaf Atef Choudhury, Ramkrishna Saha
arXiv:2602.20294v2 Announce Type: replace-cross
Abstract: Simulating real personalities with large language models requires grounding generation in authentic personal data. Existing evaluation approa...
By Yu Li, Pranav Narayanan Venkit, Yada Pruksachatkun, Chien-Sheng Wu
The paper introduces a three-tier persona vector for user simulation in evaluating LLM agents, comprising 23 dimensions across demographics, behavioral traits, and emotional states, plus a query-complexity overlay. It demonstrates that these nuanced personas generate diverse, scenario-reactive conversations, leading to significant variations in agent goal achievement and compliance across different contexts. The model’s design allows for reproducible, auditable user behavior patterns without relying on learned covariance matrices.
By Rahul Khedar, Eshita, Sneha Teja Sree Reddy Thondapu, Mayank Malhotra, Arup Kumar Das, Jitesh Chandra Mishra, Arun Menon, Avinash Karn, Mouli V
The study investigates whether coded dialogue logs from generative AI-powered virtual patients can provide teacher-interpretable evidence of clinical reasoning. Analyzing 1,030 dialogues from 210 second-year medical learners, the researchers applied behavioural prevalence, Epistemic Network Analysis, and Transition Network Analysis to identify process patterns linked to high-rated history-taking performance. Findings show that high-rated consultations involve more integrated information gathering, communication, and synthesis, rather than merely increased volume of activity.
By Xinyu Li, Zijian Li, Mengyu Xia, Luzhen Tang, Naping Chen, Changmin Lin, Danijela Gasevic, Dragan Gasevic, Yizhou Fan