arXiv:2602. 10385v5 Announce Type: replace-cross Abstract: The contemporary paradigm of trajectory learning operates fundamentally at the level of group dynamics, systematically reducing individual-level complexity to fit group-level models, thus rendering effective patient subtyping difficult and individual-level modeling largely out of reach.
arXiv:2605. 01134v3 Announce Type: replace Abstract: The dominant noun-based modeling paradigm has fundamentally constrained AI development, precluding any adequate representation of the future as an open temporal dimension.
arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.
arXiv:2608. 12779v1 Announce Type: cross Abstract: Understanding the temporal progression of symptoms in clinical narratives is critical for disease monitoring, safety surveillance, and causality assessment.
arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.
arXiv:2608.31013v1 Announce Type: new Abstract: Designing models that generalize effectively in low- to medium-data regimes remains a primary challenge in medical machine learning, particularly for p...
Understanding the temporal progression of symptoms in clinical narratives is critical for disease monitoring, safety surveillance, and causality assessment. Clinical narratives, however, rarely provide explicit temporal anchors.
arXiv:2607. 04912v1 Announce Type: cross Abstract: In patients with breast cancer, pathological complete response (pCR) has been established as a clinically meaningful surrogate marker for long-term outcomes.
MedFlow is a class‑aware multi‑scale flow matching framework designed to synthesize medical time‑series data. It uses a vector‑quantized multi‑scale tokenizer to capture both coarse and fine temporal patterns, and introduces Token Marginal Guidance to steer generation toward minority‑class characteristics. Experiments on four public datasets show MedFlow outperforms diffusion baselines, improving AUPRC by 5.8%, reducing Context‑FID by 88.6%, and achieving 3.8× higher sampling throughput.
NOAH is a generative transformer that models the entire multimodal patient journey by integrating bidirectional time and a variational latent space to capture continuous, stochastic clinical trajectories. Trained on over 559 million events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual simulations, yielding strong predictive performance across 15 ICD chapters, 29 comorbidities, and time‑to‑event outcomes.
arXiv:2607. 01145v2 Announce Type: replace Abstract: Data analysis in the medical domain often encounters scenarios involving a limited target dataset and a large, unannotated dataset with a general distribution.
arXiv:2607. 01145v1 Announce Type: new Abstract: Data analysis in the medical domain often encounters scenarios involving a limited target dataset and a large, unannotated dataset with a general distribution.
arXiv:2606. 30398v1 Announce Type: new Abstract: Accurately predicting the temporal evolution of clinical biomarkers is crucial for the early diagnosis and management of neurodegenerative diseases such as Alzheimer's disease.