arXiv:2606. 02386v1 Announce Type: new Abstract: Protein language models (PLMs) are passive oracles: they generate sequences in a single forward pass with no mechanism to consult external biophysical feedback or redirect generation when a candidate violates thermodynamic or structural constraints.
By Sahil Rahman, Maxx Richard Rahman
arXiv:2608.22132v1 Announce Type: cross
Abstract: Biomedical multi-hop question answering (QA) requires models to connect evidence across intermediate entities such as diseases, drugs, proteins, and...
By Zhaohan Meng, Zaiqiao Meng, Siwei Liu, Hao Xu, Ke Yuan, Iadh Ounis
arXiv:2609.24838v1 Announce Type: new
Abstract: Medical agents increasingly combine general reasoning models with specialized clinical tools, yet their capabilities remain largely fixed by what clini...
By Junde Wu, Jiayuan Zhu, Minghao Hu, Fenglin Liu, Jiazhen Pan
arXiv:2608. 12522v1 Announce Type: new Abstract: LLM-based program evolution systems such as FunSearch and AlphaEvolve have shown strong ability to discover novel algorithms, but typically optimize each task in isolation, discarding search experience after completion.
By Aofan Liu, Shiyuan Song, Yiyan Qi
arXiv:2602.00663v3 Announce Type: replace
Abstract: Optimizing molecules to achieve desired properties is a central bottleneck across the chemical sciences, particularly in the pharmaceutical industr...
By Fabian P. Kr\"uger, Andrea Hunklinger, Adrian Wolny, Tim J. Adler, Igor Tetko, Santiago David Villalba
arXiv:2609.24259v1 Announce Type: new
Abstract: The effectiveness of agent memory ultimately depends on whether the underlying LLM gives each memory in context an appropriate degree of influence over...
By Ruike Cao, Fanyu Zhao, Fugen Yao, Liang Dong, Jian Xu, Guanjun Jiang, Yifei Zhao, Han Zhang, Li Xiao
arXiv:2606. 09365v1 Announce Type: new Abstract: Medical agent systems are increasingly expected to support interactive clinical decision making rather than only static question answering.
By Haoran Sun, Wenjie Li, Yujie Zhang, Zekai Lin, Fanrui Zhang, Kaitao Chen, Xingqi He, Yichen Li, Mianxin Liu, Lei Liu, Yankai Jiang
arXiv:2608. 12428v1 Announce Type: new Abstract: Memory is a core component of AI agents, enabling them to accumulate experience, maintain personalization, and adapt over long-term interactions.
By Kaichao Liang, Yuqi Cui, Hao Kong, Xinyuan Huang, Guohaotian Hou, Qingcan Kang, Liang Chen, Yiyang Yin, Ke Ye, Jiaquan Guo, Da Chen, Lingan Zeng, Yixing Peng, Rong Yao, Shixiong Kai, Mingxuan Yuan
MoLRSI is a recursive self‑improving AI agent designed for molecular discovery that optimizes both workflow and model architecture using persistent cross‑task memory. It refines its search policy based on workflow performance, refinement outcomes, and execution feedback, enabling continuous improvement. In antibiotic discovery, MoLRSI achieved a 15.9% experimental hit rate versus 8.7% for an expert‑led workflow, and in de novo peptide‑MHC binder design it produced eight validated hits with preferential binding, outperforming a baseline approach.
By Yikun Zhang, Xiwei Cheng, Mingze Yuan, Yu Zhang, Brian Shim, Aarti Krishnan, Daniel Rosen, Kunyang Sun, Yingze Wang, Zhenfeng Deng, Botao Yu, Bingxu Liu, David Liu, Tianyu Liu, Yuanqi Du, Nir Hacohen, James J. Collins, Wengong Jin
Medical agent systems are increasingly expected to support interactive clinical decision making rather than only static question answering. In such settings, effective agents must reuse prior experience across evolving cases, yet existing memory mechanisms often retain raw historical traces that are redundant, noisy, and difficult to govern.
arXiv:2606. 00619v1 Announce Type: cross Abstract: Long-horizon autonomous agents require memory systems to retain historical information, track evolving states, and reuse relevant knowledge beyond finite context windows.
By Qingshan Liu, Guoqing Wang, Wen Wu, Jingqi Huang, Xinqi Tao, Dejia Song, Jie Zhou, Liang He
arXiv:2608. 14621v1 Announce Type: cross Abstract: Long-term memory is increasingly central to LLM agents, yet memory design remains a highly coupled architecture problem: what to encode, how to store it, how to retrieve it, and how to manage it can vary substantially across tasks and backbone models.
By Lin Du, Jie Zhou, Yuxuan Cai, Kai Chen, Qin Chen, Xin Li, Bo Zhang, Wei Li, Liang He