MedResearcher‑R1 is a medical deep‑research agent that uses a Knowledge‑Informed Trajectory Synthesis (KISA) framework to build medical knowledge graphs and generate complex multi‑hop question‑answer pairs, especially for rare medical entities. It also incorporates a medical retrieval engine and general‑purpose tools to reliably synthesize medical evidence. The resulting 2,100+ trajectories across 12 specialties enable supervised fine‑tuning and reinforcement learning, producing a 32B model that outperforms larger proprietary systems on MedBrowseComp and shows strong performance on GAIA and xBench benchmarks.
By Ailing Yu, HaoYang Hong, Lan Yao, Jingnan Liu, Zhe Chen, Jiajun Yin, Yuan Wang, Xinhao Liao, Zhiling Ye, Ji Li, Yun Yue, Hansong Xiao, Hualei Zhou, Chunxiao Guo, Peng Wei, Junwei Liu, Jinjie Gu
arXiv:2610.08327v1 Announce Type: new
Abstract: Large language models (LLMs) have shown promise in medical question answering and clinical reasoning, yet their improvement remains constrained by stat...
By Xilin Dang, Weilin Ruan, Xue Yang, Jinghao Wang, Xiaowei Hu, Jinpeng Li, Pheng-Ann Heng
The paper introduces a challenge‑aware adaptive recruitment system for medical multi‑agent reasoning. An external CHALLENGER monitors the evolving reasoning trace to detect factual or expertise gaps, triggering targeted knowledge retrieval or specialist recruitment mid‑discussion. Experiments on the MEDAGENTSBENCH hard subset show that challenge‑aware in‑between retrieval and Challenger‑triggered specialist recruitment improve accuracy, while naive combinations degrade performance, underscoring the importance of timing and coordination in resource recruitment.
By Riccardo Riccio, Haitz S\'aez de Oc\'ariz Borde, Pietro Li\`o
arXiv:2607. 06452v1 Announce Type: cross Abstract: Biomedical question answering requires not only accurate extraction of information from scientific literature but also reliable integration of evidence across multiple documents.
By Taeyun Roh, Eunha Lee, Wonjune Jang, Sohyun Chung, Junha Jung, Jaewoo Kang
arXiv:2603. 03292v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields.
By Wenhao Wu, Zhentao Tang, Yafu Li, Shixiong Kai, Mingxuan Yuan, Zhenhong Sun, Chunlin Chen, Zhi Wang
arXiv:2601. 07055v2 Announce Type: replace Abstract: As high-quality data becomes increasingly difficult to obtain, self-evolution without curated training data has emerged as a promising paradigm.
By Zhenrui Yue, Kartikeya Upasani, Xianjun Yang, Suyu Ge, Shaoliang Nie, Yuning Mao, Zhe Liu, Dong Wang
arXiv:2609.15161v1 Announce Type: cross
Abstract: Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strate...
By Dongsheng Shi, Yue Li, Xin Yi, Linlin Wang
arXiv:2606. 09365v1 Announce Type: new Abstract: Medical agent systems are increasingly expected to support interactive clinical decision making rather than only static question answering.
By Haoran Sun, Wenjie Li, Yujie Zhang, Zekai Lin, Fanrui Zhang, Kaitao Chen, Xingqi He, Yichen Li, Mianxin Liu, Lei Liu, Yankai Jiang
arXiv:2608.30556v1 Announce Type: new
Abstract: Path-finding over knowledge graphs has become an effective way to ground LLM reasoning on multi-hop questions. However, biomedical QA introduces two di...
By Jun Hyeong Kim, Dongki Kim, Yinhua Piao, Sung Ju Hwang
arXiv:2610.14465v1 Announce Type: cross
Abstract: Structured knowledge retrieval acquires task-relevant evidence from structured knowledge sources for downstream tasks. Existing methods rely on uncon...
By Zhisheng Qi, Haoyu Han, Jiaxi Li, Bing He, Huiyuan Chen, Franck Dernoncourt, Ryan A. Rossi, Mahantesh M. Halappanavar, Jin Lu, Yu Zhang, Tianming Liu, Yu Wang
arXiv:2602. 17911v3 Announce Type: replace-cross Abstract: Current biomedical question answering (QA) systems often assume that medical knowledge applies uniformly, yet real-world clinical reasoning is inherently conditional: nearly every decision depends on patient-specific factors such as comorbidities and contraindications.
By Jash Rajesh Parekh, Wonbin Kweon, Joey Chan, Rezarta Islamaj, Robert Leaman, Pengcheng Jiang, Chih-Hsuan Wei, Zhizheng Wang, Zhiyong Lu, Jiawei Han
arXiv:2505. 15062v5 Announce Type: replace-cross Abstract: Knowledge extrapolation is the process of inferring novel information by combining and extending existing knowledge that is explicitly available.
By Jiashu He, Jinxuan Fan, Bowen Jiang, Ignacio Houine, Dan Roth, Alejandro Ribeiro