arXiv Machine Learning

Recovering Candidate Circadian Regulators of Arrhythmic Pituitary Hormone Genes Using Reliability-Weighted Magnetic Laplacian with rwMagLap

arXiv:2607. 06579v1 Announce Type: cross Abstract: We study how to recover candidate circadian-clock regulators of pituitary hormone genes that are important for women's health but do not show a clear 24-hour rhythm in bulk tissue, aiming to nominate clock-linked regulatory targets that could inform future chronopharmacologic and chronotherapeutic strategies.

arXiv AI
Sep 3

FemWear: A Parameter-Efficient Wearable Foundation Model for Women's Health

FemWear is a parameter‑efficient wearable foundation model specifically tailored for women's health. It repurposes a pretrained multimodal wearable backbone by training only 239,236 encoder parameters—just 1.11% of the original 21.54M—using low‑rank residual adapters and causal task‑family heads to create a shared longitudinal representation for menstrual, symptom, affective, sleep/recovery, autonomic, activity, and pregnancy outcomes. Evaluations across six cohorts and 63 metrics show improvements in cycle‑phase macro‑F1 and reductions in mean absolute error for cramps, mood symptoms, and sleep problems, while maintaining the OpenMHC ability‑retention benchmark.

By Yifan Wang, Chenzhong Li
arXiv Machine Learning
Oct 12

DyssomniaNN: Multi-Scale Spiking Neural Modeling of Human Sleep Disorders and Perceived Restedness

DyssomniaNN is a multi‑scale computational model that integrates Borbely’s two‑process sleep regulation, Saper’s hypothalamic flip‑flop circuit, and a corticothalamic spiking neural network to simulate human sleep disorders. The model reproduces empirical EEG spectra across five clinical cohorts—healthy control, delayed‑phase circadian rhythm disorder, chronic insomnia, paradoxical insomnia, and narcolepsy type 1—within a 72‑hour photoperiod. Introducing the Well‑Rested Index, the simulations show that total sleep time does not reliably predict restorative recovery, as exemplified by paradoxical insomnia’s normal sleep duration but low restoration and narcolepsy’s severe nocturnal fragmentation.

By Daniel Szelogowski
arXiv Machine Learning
Jun 2

Torus Graphs for Large Scale Neural Phase Analysis

arXiv:2606. 00496v1 Announce Type: new Abstract: Oscillatory neural signals such as electroencephalography (EEG) and local field potentials (LFPs) show phase relationships that coordinate communication across brain regions.

By Jack Goffinet, Casey Hanks, David E. Carlson
arXiv Machine Learning
Jul 2

Timesynth: A Temporal Fidelity Framework for Health Signal Digital Twins

arXiv:2607. 00431v1 Announce Type: new Abstract: Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost.

By Md Rakibul Haque, Shireen Elhabian, Warren Woodrich Pettine
arXiv Machine Learning
Jul 21

Differentiable latent structure discovery for interpretable forecasting in clinical time series

arXiv:2604. 27967v2 Announce Type: replace Abstract: Background: We introduce StructGP, a continuous-time multi-task Gaussian process that couples process convolutions with differentiable structure learning to uncover a sparse, ordered directed acyclic graph (DAG) of inter-variable dependencies while preserving principled uncertainty.

By Ivan Lerner, Jean Feydy, Alexandre Kalimouttou, Anita Burgun, Francis Bach
arXiv Computation and Language
1d ago

ARTA: Graph Combinatorial Optimization for Robust Interbeat Interval Estimation from Wearable Electrocardiogram Signals

ARTA is a graph‑based combinatorial framework that improves interbeat interval estimation from wearable ECG by integrating candidates from multiple detectors into a directed acyclic graph. It uses detector agreement, ECG quality, and history‑dependent transition costs to select a coherent heartbeat sequence via beam‑search dynamic programming, effectively suppressing false detections and recovering missed beats. On benchmark datasets, ARTA reduces heart‑rate mean absolute error by 54% compared to the best single detector and achieves high accuracy in R‑peak detection and IBI estimation while remaining lightweight and training‑free.

By Shovito Barua Soumma, Asiful Arefeen, Hassan Ghasemzadeh
arXiv Machine Learning
Aug 4

Automated ECG Interval Measurement and Wave Delineation Using Fast Fourier Convolution ResNet

arXiv:2608. 00058v1 Announce Type: cross Abstract: Accurate measurement of ECG intervals, including PR, QRS duration, and QT/QTc, is central to cardiac diagnosis, yet the published ECG delineation literature evaluates performance almost exclusively as fiducial-point timing errors on small curated databases, rather than as clinical interval accuracy on large unselected cohorts.

By Farhan Adam Mukadam, Harshit Mishra, Nachiket Makwana, Pradyot Tiwari, Subramani Kandasamy, KVS Hari
arXiv AI
Sep 7

BioSync: Transformer-Based Cross-Modal Fusion for a Multimodal Physiological Digital Biomarker

BioSync is a transformer-based model that fuses cardiac, neural, behavioral, and speech data from wearables and mobile devices into a continuous composite digital biomarker called the BioSync Index (BSI). The architecture uses multi-head self-attention on modality tokens and a linear branch for feature concatenation, inspired by latent-variable measurement theory. Evaluations on synthetic cohorts for cognitive decline and metabolic-autonomic conditions show BioSync achieving AUCs of 0.928 and 0.764 accuracy/F1 of 0.766, outperforming simple concatenation and other fusion strategies in most corruption scenarios.

By Seyed Mahmoud Sajjadi Mohammadabadi