BioSync is a transformer-based model that fuses cardiac, neural, behavioral, and speech data from wearables and mobile devices into a continuous composite digital biomarker called the BioSync Index (BSI). The architecture uses multi-head self-attention on modality tokens and a linear branch for feature concatenation, inspired by latent-variable measurement theory. Evaluations on synthetic cohorts for cognitive decline and metabolic-autonomic conditions show BioSync achieving AUCs of 0.928 and 0.764 accuracy/F1 of 0.766, outperforming simple concatenation and other fusion strategies in most corruption scenarios.
arXiv:2607. 11656v1 Announce Type: cross Abstract: Accurate diagnostic classification and disease-severity prediction for Alzheimer's disease are hampered by the incompleteness and heterogeneity of real-world clinical data.
The paper presents a modality‑agnostic, hierarchical Transformer framework for assessing cognitive workload using heterogeneous biosignals. In a pilot study, the authors evaluated all 31 combinations of five modalities (ECG, EDA, RESP, SpO₂, EEG) across three tasks (IQ, MATH, GAME) and found that EEG alone performed best, while adding more modalities did not consistently improve results. The full five‑modality model achieved the highest average accuracy (73.02% on IQ, 68.08% overall) and reduced model size by about 50% compared to late‑fusion approaches.
arXiv:2411. 15240v5 Announce Type: replace-cross Abstract: Wearable movement data is collected by nearly all commercially available smartwatches and is a valuable resource for mental health research, reflecting fine-grained temporal behavioral trends.
arXiv:2607. 24519v3 Announce Type: replace-cross Abstract: EEG foundation-model gains may depend on cohort, montage, or probe design.
arXiv:2607. 28687v1 Announce Type: cross Abstract: As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs.
arXiv:2607. 24519v2 Announce Type: replace Abstract: Pretrained EEG foundation models are proposed for clinical decoding, but whether reported gains transfer across populations or survive negative controls is unclear.
arXiv:2606. 30646v1 Announce Type: cross Abstract: Speech recruits the same executive, attentional, and working memory processes underlying instrumental activities of daily living, or IADLs, providing a non-invasive proxy for cognitive assessment.
arXiv:2607. 25232v2 Announce Type: replace Abstract: Digital phenotyping (DP) using smartphones and wearable devices has shown considerable potential for mental health monitoring.
The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
arXiv:2607. 06629v1 Announce Type: new Abstract: Brain age -- the age inferred from a physiological recording -- is an emerging biomarker whose deviation from chronological age tracks neurological and psychiatric burden, and EEG is an attractive substrate for it because it is cheap, portable, and temporally rich.
arXiv:2609.14764v1 Announce Type: cross Abstract: Early detection of cognitive decline from speech offers a scalable and non-invasive alternative to conventional clinical assessment. Verbal fluency t...
arXiv:2607. 22264v1 Announce Type: new Abstract: Autoregressive foundation models trained on tokenized electronic health records (EHRs) can support zero-shot clinical prediction, yet most operate on structured event codes alone, and do not incorporate multiple modalities in a principled way.