arXiv Machine Learning

FedDOSE: Federated Learning Framework Decomposing Site Effects for Modeling Brain Dynamic Functional Connectivity

arXiv:2608. 07393v1 Announce Type: new Abstract: Functional Magnetic Resonance Imaging ( fMRI ) data are often pooled into collaborative multi-site consortia, as deep learning models for analyses require large datasets to generalize well.

arXiv Machine Learning
Jul 30

An Attention-Based Framework for Alzheimers Disease Classification Using Resting-State fMRI

arXiv:2607. 26746v1 Announce Type: cross Abstract: Accurate identification of Alzheimers disease (AD) using resting-state functional magnetic resonance imaging (rs-fMRI) remains challenging due to the high dimensionality, noise, and complex inter-regional dependencies inherent in functional brain connectivity, which limit the effectiveness of traditional approaches based on handcrafted connectivity features or conventional machine learning models.

By Harshiddhi Pathak, Gowtham Reddy N, Mrinal Acharya, Manjunatha Mahadevappa
arXiv Computer Vision
Sep 24

A generalizable structural brain MRI foundation model built through dual-priority federated pretraining

BrainFedFM is a structural brain MRI foundation model that was federatively pretrained on 164,707 3‑D scans from 42 sites using a dual‑priority approach that emphasizes informative anatomical regions locally and prioritizes site contributions globally. The model outperformed seven baseline models—including four centralized foundation models—across 20 downstream tasks (classification, regression, segmentation), achieving a mean rank of 1.68 and a 50% performance gain, especially in classification and regression and among underrepresented populations. These results demonstrate the model’s generalizability and show that federated pretraining can effectively develop neuroimaging foundation models without pooling raw images.

By Zhen Yu, Yang Liu, Xiahai Zhuang, Qingchao Chen
arXiv Machine Learning
Aug 27

MSR-IVA: Masked Structural Residual Independent Vector Analysis for State-Aware Fusion of Structural MRI and Dynamic Functional Network Connectivity

The paper introduces MSR-IVA, a state-aware fusion method that combines a shared structural representation with state‑specific residual adaptations and masks for incomplete state expression. Applied to an Alzheimer’s Disease Neuroimaging Initiative cohort, MSR-IVA increased matched source coupling by 6.5% and decreased unmatched dependence by 15.7% compared to a baseline IVA approach. For subjects expressing both states, the method achieved a mean absolute cross‑state structural source correlation of 0.9177, far higher than the 0.2978 obtained without sharing, indicating effective preservation of source correspondence while allowing state‑specific adaptation.

By Victor Solomon, Zening Fu, Rafal Angryk, Vince D. Calhoun, Jingyu Liu
arXiv AI
Jun 9

NeuroAlign: Hierarchical Multimodal Fusion of Dynamic and Structural Neuroimaging for MCI Analysis

arXiv:2606. 07635v1 Announce Type: cross Abstract: Multimodal neuroimaging fusion of functional MRI (fMRI) and diffusion tensor imaging (DTI) provides complementary information for cognitive impairment analysis, but remains challenged by heterogeneous feature spaces and misaligned representations.

By Xiongri Shen, Zhenxi Song, Jiaqi wang, Yi Zhong, Leilei Zhao, Chenqi Xu, Linling Li, Yichen Wei, Lingyan Liang, Demao Deng, Luping Song, Ping Luan, Ahmed M. Anter, Shuqiang Wang, Baiying Lei, Zhiguo Zhang