arXiv Machine Learning

How to train your model organism

arXiv Machine Learning
Jul 2

The Model Organism Lottery: Model Organism Interpretability Strongly Depends on Training Methodology

arXiv:2607. 01033v1 Announce Type: new Abstract: Model organisms (MOs) - language models trained to exhibit undesired or unnatural behaviours - are frequently used as testbeds for evaluating white-box interpretability techniques.

By Andrzej Szablewski, Gabriel Konar-Steenberg, Raffaello Fornasiere, Nikita Menon, Stefan Heimersheim
arXiv AI
Oct 7

SIGMA: Self-Improving Alignment Generalization from a Model Spec

SIGMA is a self‑improving alignment framework that uses a model’s own reasoning to generate diverse alignment dilemma scenarios from a simple "Model Spec" and then fine‑tunes the model with self‑judged rewards. By performing spec‑guided task synthesis and rubric‑based reinforcement learning, SIGMA improves safety alignment in multi‑turn agentic settings, reducing harmfulness and misalignment scores while preserving general capability. The approach demonstrates that a model can autonomously strengthen its own safety reasoning without external supervision.

By Jingyu Zhang, Shruti Palaskar, Daniel Khashabi, Benjamin Van Durme, Leon A. Gatys, Joseph Yitan Cheng
arXiv Machine Learning
Oct 5

Clinical Concept Centers in LLMs

The paper investigates whether clinical concepts are represented as distinct, causally influential centers within the latent space of large language models (LLMs). By evaluating eleven open-weight LLMs, the authors discover that each model contains dedicated clinical concept centers that are interpretable, activate only on relevant clinical narratives, and drive model behavior in both constrained and open-ended contexts. These centers can be leveraged for evaluation and performance improvement, as steering models along them enhances downstream clinical outcomes and aligns with clinician preferences.

By Aishik Nagar, Abhishek Vaidyanathan, Arun-Kumar Kaliya-Perumal, Elijah Tzen Hsuen Boey, Stefan Winkler
arXiv Machine Learning
Jun 2

OncoReason: Structuring Clinical Reasoning in LLMs for Robust and Interpretable Survival Prediction

arXiv:2510. 17532v2 Announce Type: replace-cross Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data.

By Raghu Vamshi Hemadri, Geetha Krishna Guruju, Kristi Topollai, Anna Ewa Choromanska
arXiv Machine Learning
Jul 9

Counterfactual Modeling with Fine-Tuned LLMs for Health Intervention Design and Sensor Data Augmentation

arXiv:2601. 14590v3 Announce Type: replace Abstract: Counterfactual explanations (CFEs) provide human-centric interpretability by identifying the minimal, actionable changes required to alter a machine learning model's prediction.

By Shovito Barua Soumma, Asiful Arefeen, Stephanie M. Carpenter, Melanie Hingle, Hassan Ghasemzadeh
arXiv Machine Learning
Aug 7

Clinician input steers AI toward accurate and harmful recommendations

arXiv:2603. 14158v2 Announce Type: replace-cross Abstract: Large language models (LLMs) are entering clinical workflows, yet evaluations rarely assess how clinician reasoning shapes model behavior during clinical interactions.

By Ivan Lopez, Selin S. Everett, Bryan J. Bunning, April S. Liang, Dong Han Yao, Shivam C. Vedak, Kameron C. Black, Sophie Ostmeier, Stephen P. Ma, Emily Alsentzer, Jonathan H. Chen, Akshay S. Chaudhari, Eric Horvitz
arXiv Machine Learning
Sep 22

Characterizing Model-Native Skills

arXiv:2604.17614v2 Announce Type: replace-cross Abstract: Skills are a natural unit for describing what a language model can do and how its behavior can be changed. However, existing characterization...

By Feiyang Kang, Mahavir Dabas, Myeongseob Ko, Ruoxi Jia