arXiv AI

Navigating Hierarchy: Hyperbolic Learning on Brain Graphs for Disorder Diagnosis

arXiv:2607. 07077v1 Announce Type: cross Abstract: Functional brain networks exhibit a hierarchical organization across ROI, community, and whole-brain levels, supporting local processing, inter-community coordination, and global integration.

arXiv AI
3d ago

BrainNet Studio: A Unified Toolkit for Brain Network Construction, Intelligent Analysis, and Visualization

BrainNet Studio is a unified toolkit that enables the construction, analysis, and visualization of both static and dynamic brain networks. It integrates 27 algorithms—including deep learning, graph neural networks, and spatiotemporal sequence models—to support classification, biomarker identification, and the extraction of discriminative brain regions and connections. The toolkit also employs a large language model to generate researcher‑verifiable summaries of functional and structural connectivity, as well as structure‑function coupling, at individual and group levels.

By Xiwei Zeng, Shengrong Li, Yiheng Liu, Chunwei Tian, Daoqiang Zhang, Qi Zhu
arXiv Machine Learning
Sep 16

Explainable Graph-theoretical Machine Learning with Application to Alzheimer's Disease Prediction

The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.

By Narmina Baghirova, Duy-Thanh V\~u, Duy-Cat Can, Christelle Schneuwly Diaz, Julien Bodlet, Guillaume Blanc, Georgi Hrusanov, Bernard Ries, Oliver Y. Ch\'en
arXiv AI
Sep 17

Hyperbolic Graph Representation Learning for Differential Diagnosis on Biomedical Knowledge Graphs

The paper investigates hyperbolic graph representation learning applied to biomedical knowledge graphs for Mendelian-disease differential diagnosis. It shows that hyperbolic embeddings outperform Euclidean baselines on isolated ontology subgraphs while requiring fewer dimensions. In a link-prediction task, hyperbolic models rank candidate diseases for patients, indicating they can leverage hierarchical structure in heterogeneous patient-level graphs.

By Pietro Miotto, Lucia Mellini, Tommaso Marzi, Cesare Alippi, Elena Casiraghi, Alberto Paccanaro, Giorgio Valentini, Mauricio Soto-Gomez