arXiv Machine Learning

Group ICA 2.0: Closing the Gap Between Subjects and Group Latent Decomposition with Copula-Linked Group ICA (CoLiG-ICA)

arXiv:2608. 16029v1 Announce Type: new Abstract: Group Independent Component Analysis (gICA) is widely used to decompose high-dimensional functional MRI data into interpretable brain networks.

arXiv Machine Learning
Aug 27

MSR-IVA: Masked Structural Residual Independent Vector Analysis for State-Aware Fusion of Structural MRI and Dynamic Functional Network Connectivity

The paper introduces MSR-IVA, a state-aware fusion method that combines a shared structural representation with state‑specific residual adaptations and masks for incomplete state expression. Applied to an Alzheimer’s Disease Neuroimaging Initiative cohort, MSR-IVA increased matched source coupling by 6.5% and decreased unmatched dependence by 15.7% compared to a baseline IVA approach. For subjects expressing both states, the method achieved a mean absolute cross‑state structural source correlation of 0.9177, far higher than the 0.2978 obtained without sharing, indicating effective preservation of source correspondence while allowing state‑specific adaptation.

By Victor Solomon, Zening Fu, Rafal Angryk, Vince D. Calhoun, Jingyu Liu
arXiv AI
Sep 21

Rhamba: Region-Aware Hybrid Attention-Mamba Framework for Self-Supervised Learning in Resting-State fMRI

Rhamba is a region‑aware pretraining framework for resting‑state fMRI that combines anatomically guided masking with hybrid Attention‑Mamba architectures. The study pretrained models on the ABIDE dataset using three masking strategies (Any, Majority, Pure) and evaluated four architectural variants, finding that the Mamba‑Attention (MA) hybrid achieved the best average AUROC on downstream schizophrenia and ADHD classification tasks. Explainable AI via Integrated Gradients highlighted that performance depends on the interaction between masking strategy and architecture rather than a single dominant configuration.

By Pankaj Pandey, Ruthwik Reddy Doodipala, Pratheek Eranki, Carolina Torres-Rojas, Manob Jyoti Saikia, Ranganatha Sitaram
arXiv AI
Jun 12

BrainDINO: A Brain MRI Foundation Model for Generalizable Clinical Representation Learning

arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.

By Yizhou Wu, Shansong Wang, Yuheng Li, Mojtaba Safari, Mingzhe Hu, Chih-Wei Chang, Harini Veeraraghavan, Xiaofeng Yang
arXiv Machine Learning
Jun 5

Cross-scale spatially-aware generative modeling of transcriptomic programs underlying neurodegenerative brain organization

arXiv:2606. 05870v1 Announce Type: cross Abstract: Neurodegenerative disorders such as Alzheimer's disease exhibit highly organized patterns of regional brain vulnerability, yet the biological mechanisms underlying this spatial selectivity remain incompletely understood.

By Krishnakumar Vaithianathan (for the Alzheimer's Disease Neuroimaging Initiative)
arXiv Computer Vision
Sep 14

Learning Sparse Latent Predictive Foundation Model for Multimodal Neuroimaging

The paper introduces Neuro‑JEPA, a sparse multimodal foundation model that learns unified representations of brain MRI across T1w, T2w, and FLAIR sequences using a latent predictive objective and a Mixture‑of‑Experts architecture. It was pretrained on over 1.5 million scans from 428,647 studies and systematically evaluates architectural, masking, objective, and sparsity choices for robust multimodal representation learning. Across 47 tasks from three health systems and 12 public datasets, Neuro‑JEPA consistently outperforms a simple CNN baseline, demonstrating its effectiveness for both clinical and research applications.

By Haoxu Huang, Long Chen, Jingyun Chen, Jinu Hyun, James Ryan Loftus, Kara Melmed, Daniel Orringer, Jennifer Frontera, Seena Dehkharghani, Arjun Masurkar, Narges Razavian
arXiv AI
Jun 9

NeuroAlign: Hierarchical Multimodal Fusion of Dynamic and Structural Neuroimaging for MCI Analysis

arXiv:2606. 07635v1 Announce Type: cross Abstract: Multimodal neuroimaging fusion of functional MRI (fMRI) and diffusion tensor imaging (DTI) provides complementary information for cognitive impairment analysis, but remains challenged by heterogeneous feature spaces and misaligned representations.

By Xiongri Shen, Zhenxi Song, Jiaqi wang, Yi Zhong, Leilei Zhao, Chenqi Xu, Linling Li, Yichen Wei, Lingyan Liang, Demao Deng, Luping Song, Ping Luan, Ahmed M. Anter, Shuqiang Wang, Baiying Lei, Zhiguo Zhang