arXiv Computer Vision

Medical Image Alignment Assessment as a Test of Generalist Visual Reasoning in Frontier Multimodal Models

arXiv AI
Jun 11

OpenMedReason: Scientific Reasoning Supervision for Medical Vision-Language Models

arXiv:2606. 12169v1 Announce Type: cross Abstract: High-stakes clinical use of large vision-language models (LVLMs) requires reasoning that is grounded in visual evidence and clinical knowledge, not just correct final answers.

By Negin Baghbanzadeh, Pritam Sarkar, Michael Colacci, Abeer Badawi, Adibvafa Fallahpour, Arash Afkanpour, Leonid Sigal, Ali Etemad, Elham Dolatabadi
arXiv AI
Aug 28

From Reasoning to Pixels: Grounded Medical Multimodal LLMs for VQA and Segmentation

The paper introduces MedREAL, a unified framework that aligns linguistic reasoning with spatial grounding for medical visual question answering and segmentation. MedREAL employs Seg Anchored Reasoning Pooling (SARP) to extract semantic evidence from segmentation tokens and a Reasoning-to-Visual (R2V) fusion mechanism to integrate these features into a segmentation pipeline. Using the newly created MedRAVS-13K dataset, MedREAL achieves superior performance, reporting 68.49% gIoU and 70.47% cIoU, and generates evidence masks that consistently match textual diagnoses.

By Haowen Gu, Gensheng Pei, Junzhu Mao, Qiong Wang, Mingwu Ren, Yazhou Yao
arXiv AI
Oct 1

From Compound Figures to Medical Multi-image Reasoning: Scaling Multimodal Large Language Models with Biomedical Literature

arXiv:2511.22232v2 Announce Type: replace-cross Abstract: Multimodal large language models (MLLMs) are increasingly capable in medical imaging, yet most focus on single-image settings. Clinical inter...

By Zhen Chen, Yihang Fu, Rong Zhou, Serina Applebaum, Min Kyu Kim, Aidan Gilson, Morten Lee, Salahudeen Mirza, Gabriel Madera, Mauro Giuffre, Yuanting Pan, Roy Jiang, Hyunjae Kim, Hua Xu, Qingyu Chen
arXiv AI
Jun 30

IMCBench: A benchmark for multimodal LLMs in Image-grounded Medical Conversations

arXiv:2606. 28556v1 Announce Type: new Abstract: Recent advances in large language models and vision-language models have enabled reasoning over multimodal data, offering opportunities for clinical applications such as decision support and triaging.

By Maria Xenochristou, Ashutosh Joshi, Korosh Vatanparvar, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Anchal Nema, Nivedita Wadhwa, Prashams S Jain, Rebecca Abraham, Will Kimbrough, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv Computer Vision
Aug 25

SynerMedGen: Synergizing Medical Multimodal Understanding with Generation via Task Alignment

SynerMedGen is a unified framework that aligns medical multimodal understanding with generation tasks through task alignment. It introduces three generation‑aligned understanding tasks and a two‑stage training strategy that transfers representations learned during understanding to medical image synthesis. The model achieves strong zero‑shot performance on 22 synthesis tasks and outperforms state‑of‑the‑art specialized and unified models when combined with generation training, supported by a new 1M‑sample SynerMed dataset.

By Weiren Zhao, Yi Dong, Cheng Chen
arXiv Computation and Language
Sep 22

Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning

Lingshu is a medical‑specialized multimodal large language model that addresses key limitations of existing medical MLLMs, such as narrow knowledge coverage, hallucinations, and weak reasoning. The authors curate a comprehensive dataset combining medical imaging, texts, and general‑domain data, then train Lingshu in multiple stages to embed medical expertise and improve task performance. They also introduce MedEvalKit, a unified evaluation framework, and demonstrate that Lingshu outperforms current open‑source multimodal models on multimodal QA, text‑based QA, and medical report generation.

By Weiwen Xu, Hou Pong Chan, Long Li, Mahani Aljunied, Ruifeng Yuan, Jianyu Wang, Chenghao Xiao, Guizhen Chen, Chaoqun Liu, Zhaodonghui Li, Yu Sun, Junao Shen, Chaojun Wang, Jie Tan, Deli Zhao, Tingyang Xu, Hao Zhang, Yu Rong
arXiv AI
Sep 17

A visual large language foundational model for medical image recognition using clinician-contributed online resources

The paper introduces ThoughtMed-1M, a large-scale medical visual question answering dataset built from de‑identified images and clinician‑generated commentaries, designed to capture structured clinical reasoning and image‑text alignment. Using this dataset, the authors train FOLTMed, a foundational large language model that achieves state‑of‑the‑art performance on 42 medical VQA benchmarks, with a macro accuracy of 85.4% and improved factuality and similarity metrics over existing models.

By Lingxuan Hou, Yuhua Xie, Yue Hu, Yan Zhuang, Junqi Li, Chengzhi Xia, Binh Phu Nguyen, Abubakar Siddique, Minh Nguyen, Yao Hou, Yanju Bao, Kexin Liu, Ke Chen, Jianjun Sun, Zeqi Li, Trung Nguyen, Jiangli Lin
arXiv Computation and Language
Sep 1

UReason: Benchmarking Reasoning-to-Generation Alignment in Unified Multimodal Models

UReason is a benchmark that evaluates how well unified multimodal models (UMMs) align textual reasoning with image generation. It contains 2,000 human‑curated instances across five reasoning‑intensive tasks—Code, Arithmetic, Spatial, Attribute, and Text—and compares direct generation, reasoning‑guided generation, and decontextualized generation. The study finds that while reasoning‑guided generation improves over direct generation, decontextualized generation consistently outperforms it, indicating that the visual semantics in textual reasoning are not reliably reflected in the generated images.

By Cheng Yang, Chufan Shi, Bo Shui, Yaokang Wu, Muzi Tao, Huijuan Wang, Ivan Yee Lee, Yong Liu, Xuezhe Ma, Taylor Berg-Kirkpatrick
arXiv AI
Sep 10

A visual large language foundational model for medical image recognition using clinician-oriented social media

arXiv:2609.06914v1 Announce Type: new Abstract: Large language models (LLMs) have demonstrated strong capabilities across diverse domains, showing considerable potential in medicine. However, their a...

By Lingxuan Hou, Yuhua Xie, Yue Hu, Yan Zhuang, Junqi Li, Chengzhi Xia, Binh Phu Nguyen, Abubakar Siddique, Minh Nguyen, Yao Hou, Yanju Bao, Kexin Liu, Ke Chen, Jianjun Sun, Zeqi Li, Trung Nguyen, Jiangli Lin
arXiv Machine Learning
Jun 26

Staying VIGILant: Mitigating Visual Laziness via Counterfactual Visual Alignment in MLLMs

arXiv:2606. 26387v1 Announce Type: cross Abstract: Multimodal large language models (MLLMs) extend large language models (LLMs) with visual perception, enabling joint reasoning over images and text.

By Xi Xiao, Chen Liu, Chih-Ting Liao, Yunbei Zhang, Qizhen Lan, Yuxiang Wei, Lin Zhao, Janet Wang, Jianyang Gu, Muchao Ye, Tianyang Wang, Hao Xu