arXiv AI

From Compound Figures to Medical Multi-image Reasoning: Scaling Multimodal Large Language Models with Biomedical Literature

arXiv Computation and Language
Sep 23

MultiViewDx: Evidence-Linked Multi-View Clinical Diagnosis

MultiViewDx is a physician‑validated multimodal instruction dataset that links medical imaging studies with patient context and normalizes heterogeneous reports into an evidence‑linked workflow (evidence → findings → differential discussion → diagnosis). The dataset covers a wide range of imaging modalities and uses a unified image‑text retriever to ensure that instruction synthesis is grounded in source‑supported evidence. Fine‑tuned models on MultiViewDx achieve the highest average accuracy on four MedVQA benchmarks and receive the strongest overall rating on JAMA Clinical Challenge cases, with ablations confirming the importance of case‑level multi‑view organization and evidence‑linked reasoning.

By Junda Wang, Zonghai Yao, Yujan Ting, Eric Z. Chen, Hieu Tran, Hong Yu, Weijing Huang, Terrence Chen
arXiv Computation and Language
Sep 22

Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning

Lingshu is a medical‑specialized multimodal large language model that addresses key limitations of existing medical MLLMs, such as narrow knowledge coverage, hallucinations, and weak reasoning. The authors curate a comprehensive dataset combining medical imaging, texts, and general‑domain data, then train Lingshu in multiple stages to embed medical expertise and improve task performance. They also introduce MedEvalKit, a unified evaluation framework, and demonstrate that Lingshu outperforms current open‑source multimodal models on multimodal QA, text‑based QA, and medical report generation.

By Weiwen Xu, Hou Pong Chan, Long Li, Mahani Aljunied, Ruifeng Yuan, Jianyu Wang, Chenghao Xiao, Guizhen Chen, Chaoqun Liu, Zhaodonghui Li, Yu Sun, Junao Shen, Chaojun Wang, Jie Tan, Deli Zhao, Tingyang Xu, Hao Zhang, Yu Rong
arXiv AI
Jun 30

IMCBench: A benchmark for multimodal LLMs in Image-grounded Medical Conversations

arXiv:2606. 28556v1 Announce Type: new Abstract: Recent advances in large language models and vision-language models have enabled reasoning over multimodal data, offering opportunities for clinical applications such as decision support and triaging.

By Maria Xenochristou, Ashutosh Joshi, Korosh Vatanparvar, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Anchal Nema, Nivedita Wadhwa, Prashams S Jain, Rebecca Abraham, Will Kimbrough, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv AI
Jun 11

OpenMedReason: Scientific Reasoning Supervision for Medical Vision-Language Models

arXiv:2606. 12169v1 Announce Type: cross Abstract: High-stakes clinical use of large vision-language models (LVLMs) requires reasoning that is grounded in visual evidence and clinical knowledge, not just correct final answers.

By Negin Baghbanzadeh, Pritam Sarkar, Michael Colacci, Abeer Badawi, Adibvafa Fallahpour, Arash Afkanpour, Leonid Sigal, Ali Etemad, Elham Dolatabadi
arXiv Machine Learning
Jul 9

MedPMC: A Systematic Framework for Scaling High-Fidelity Medical Multimodal Data for Foundation Models

arXiv:2607. 07673v1 Announce Type: cross Abstract: Medicine is inherently multimodal, requiring clinicians to synthesize information across diverse data streams.

By Hyunjae Kim, Dain Kim, Pan Xiao, Serina S. Applebaum, Younjoon Chung, Xuguang Ai, Yu Yin, Roy Jiang, Yuexi Du, Yawen Wei, Yiming Kong, Tuo Guo, Zhiyuan Cao, Mengmeng Du, Yuelei Fu, Yan Hu, Rui Shi, Gui Yang, Kevin W. Jin, Yuntian Liu, Yuxuan Tian, Jonathan Marquez, Zhen Chen, Sheng Zhang, Hoifung Poon, Hua Xu, Jaewoo Kang, Qingyu Chen
Hugging Face Trending Papers
Jun 3

BreastGPT: A Multimodal Large Language Model for the Full Spectrum of Breast Cancer Clinical Routine

Breast cancer remains a leading cause of cancer-related mortality among women. Its clinical management requires multimodal reasoning across a clinical workflow that spans \textit{screening}, \textit{diagnosis} and \textit{treatment planning}, where each stage involves distinct imaging modalities, task objectives, and reasoning patterns.

arXiv AI
Sep 21

LiteMedCoT-VL: Parameter-Efficient Adaptation for Medical Visual Question Answering

LiteMedCoT-VL is a parameter‑efficient pipeline that transfers chain‑of‑thought reasoning from a 235B teacher model to a 2B student model using LoRA fine‑tuning on explanation‑enriched data. The approach enables a compact vision‑language model to perform medical visual question answering without relying on image captions, achieving 64.9% accuracy on the PMC‑VQA benchmark—an 11‑point improvement over the zero‑shot Qwen3‑VL‑4B baseline. Visual grounding analysis confirms that the model bases its predictions on image content rather than textual priors.

By Runze Ma, Shunbo Jia, Haonan Lyu, Guo Liu, Caizhi Liao
arXiv Computation and Language
Sep 22

Representation-guided in-context learning for medical image interpretation with multimodal large language models

arXiv:2609.24057v1 Announce Type: cross Abstract: Medical image interpretation is central to diagnosis and care, yet adapting general-purpose multimodal large language models (MLLMs) often requires r...

By Minda Zhao, Fangyu Hu, Yan Luo, Yutong Yang, Jiahui Cai, Kaichen Zhou, Manling Li, Paul Liang, Yilun Du, Lucy Q. Shen, Mengyu Wang
arXiv Computer Vision
Sep 11

MedGEN-Bench: A Contextually Entangled Benchmark for Open-ended Multimodal Medical Generation

MedGEN-Bench is a new benchmark for open‑ended multimodal medical generation that addresses limitations in current medical visual benchmarks, such as query‑image misalignment, closed‑ended answer spaces, and text‑centric outputs. The dataset contains 6,422 image‑text pairs across six imaging modalities, 15 clinical tasks, and 27 subtasks, including VQA, image editing, and contextual multimodal generation pairs. Evaluation combines reference‑based fidelity metrics with a structured, checklist‑guided assessment by a medical VLM judge, and preliminary results show that image‑output tasks remain unsaturated while contextual augmentation improves image‑instruction similarity.

By Junjie Yang, Yuhao Yan, Gang Wu, Rui Qian, Zhisheng Chen, Haijiang Li, Yuhe Wu, Qichao Zhao, Dawen Tian, Xiang Wan, Fenglei Fan, Wenjian Qin, Yongquan Zhang, Feiwei Qin, Changmiao Wang
arXiv AI
Jul 1

Breaking Failure Cascades: Step-Aware Reinforcement Learning for Medical Multimodal Reasoning

arXiv:2606. 31825v1 Announce Type: cross Abstract: Recent multimodal large language models have shown great promise in clinical image reasoning, but existing post-training pipelines remain predominantly outcome-centric, relying on final answer correctness or sequence-level preferences.

By Junha Jung, Minbyul Jeong, Suhyeon Lim, Sungwook Jung, Jaehoon Yun, Taeyun Roh, Mujeen Sung, Jaewoo Kang