arXiv AI

Trick-or-Treat: Adversarial Evaluation of Multimodal Medical Reasoning with Synthetic Images

Trick-or-Treat is an adversarial multimodal medical benchmark that pairs real chest radiographs with synthetic clinical photographs to test cross‑modal reasoning. Each condition has matched pairs where the radiograph and photograph suggest the same disease, and mismatched pairs where the photograph shows an alternative finding. In tests of three frontier models, hallucinations of clinically significant findings rose from 25‑37.5% for single photographs to 45‑57.5% when mismatched pairs were presented, with models often ignoring mismatches and generating findings that better aligned with the radiograph.

arXiv AI
Oct 1

From Compound Figures to Medical Multi-image Reasoning: Scaling Multimodal Large Language Models with Biomedical Literature

arXiv:2511.22232v2 Announce Type: replace-cross Abstract: Multimodal large language models (MLLMs) are increasingly capable in medical imaging, yet most focus on single-image settings. Clinical inter...

By Zhen Chen, Yihang Fu, Rong Zhou, Serina Applebaum, Min Kyu Kim, Aidan Gilson, Morten Lee, Salahudeen Mirza, Gabriel Madera, Mauro Giuffre, Yuanting Pan, Roy Jiang, Hyunjae Kim, Hua Xu, Qingyu Chen
arXiv Computation and Language
Sep 4

MedQA-MM: Shortcuts Behind Medical Visual Reasoning

The paper introduces MedQA-MM, a benchmark that exposes shortcut reasoning in medical multimodal multiple-choice questions. By auditing prompts, images, and modalities, the authors show that models often rely on textual cues rather than visual evidence, with full-input accuracy at 62.63% but only 5.21% when restricted to text. The study highlights the need for route-level evidence to validate true medical image reasoning.

By Benlu Wang, Yifan Zhang, Jiaqing Yu, Chin Siang Ong, Juncheng Huang, Zhuohao Li, Zhenyu Zhang, Arman Cohan, Hong Yu, Zonghai Yao
arXiv AI
Jun 30

IMCBench: A benchmark for multimodal LLMs in Image-grounded Medical Conversations

arXiv:2606. 28556v1 Announce Type: new Abstract: Recent advances in large language models and vision-language models have enabled reasoning over multimodal data, offering opportunities for clinical applications such as decision support and triaging.

By Maria Xenochristou, Ashutosh Joshi, Korosh Vatanparvar, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Anchal Nema, Nivedita Wadhwa, Prashams S Jain, Rebecca Abraham, Will Kimbrough, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv AI
Jul 29

Evaluating Multi-Turn Multimodal Diagnostic Reasoning on Challenging Real-World Clinical Cases

arXiv:2607. 25933v1 Announce Type: cross Abstract: Clinical diagnostic evaluation should not only assess whether models can provide correct diagnoses, but also reflect the realities of clinical practice, including progressive disclosure of multimodal information, dynamic updating of diagnostic hypotheses, and continuous refinement of clinical reasoning.

By Rui Yang, Weihao Xuan, Yi Lin, Zhuhan Bao, Jonathan Chong Kai Liew, Matthew Yu Heng Wong, Nicol\'as Lescano, Nikita R. Paripati, Emily Ling-Lin Pai, Jiarui Liu, Heli Qi, Heng-Jui Chang, Benny Kai Guo Loo, Huitao Li, Kunyu Yu, Yufan Wang, Chuan Hong, Shijian Lu, Douglas Teodoro, Naoto Yokoya, Ross Koppel, Mona Diab, Hua Xu, David W. Bates, Nan Liu, Yifan Peng
arXiv AI
Aug 21

MKG-CARE: Case-Aware Reasoning with Multimodal Knowledge Graphs for Explainable Medical Image Diagnosis

arXiv:2605. 22547v3 Announce Type: replace-cross Abstract: Medical image diagnosis has achieved significant progress with deep learning, yet existing methods often rely on isolated visual evidence and lack the ability to effectively leverage similar cases and external knowledge.

By Yiming Xu, Yixuan Liu, Yuhang Zhang, Ling Zheng, Yihan Wang, Qi Song
arXiv Machine Learning
Jun 5

A Vision-language Framework for Comparative Reasoning in Radiology

arXiv:2606. 06407v1 Announce Type: cross Abstract: Medical imaging artificial intelligence has achieved strong performance in isolated image interpretation, but remains poorly aligned with radiological practice, where diagnosis and follow-up rely on comparison across prior studies and analogous reference cases.

By Tengfei Zhang, Ziheng Zhao, Lisong Dai, Xiaoman Zhang, Pengcheng Qiu, Ya Zhang, Yanfeng Wang, Weidi Xie