The paper introduces a new framework for generating medical image counterfactuals that does not rely on auxiliary generative models. By extracting causal evidence directly from a classifier, the method deterministically produces edits within user-specified regions, requiring no additional training. Experiments on real-world medical imaging datasets show that these counterfactuals alter classifier predictions while staying closer to the original image than generative baselines, offering a clearer view of the model’s decision boundary.
By David A. Kelly, Tom Yaacov, Nathan Blake, Sander Beckers, Hana Chockler
The paper introduces a new method for generating medical image counterfactuals that does not rely on auxiliary generative models. By extracting causal evidence directly from the classifier, the approach deterministically edits user-specified regions to alter predictions while staying closer to the original image than generative baselines. Experiments on real-world medical imaging datasets show that this technique provides a more direct and transparent view of the classifier’s decision boundary.
arXiv:2606. 21806v2 Announce Type: replace Abstract: Deep generative models reproduce the observational distribution of their training data, inheriting any spurious associations it contains.
By Jingyuan Chen, Kangrui Ruan, Junzhe Zhang
arXiv:2605.10894v2 Announce Type: replace
Abstract: Deep learning models in medical imaging often fail when deployed in new clinical environments due to distribution shifts in demographics, scanner h...
By Moritz Stammel, Fabio De Sousa Ribeiro, Raghav Mehta, M\'elanie Roschewitz, Ben Glocker
arXiv:2607. 02596v1 Announce Type: cross Abstract: Deep learning models for medical diagnosis frequently exhibit substantial performance disparities across sensitive subgroups (e.
By Xinyu Jia, Weidong Guo, Wangyuan Zhao, Yi Guo, Zeju Li, Yuanyuan Wang
The paper introduces a classifier‑free method for generating visual counterfactual explanations (VCEs) using Contrastive Analysis (CA). By separating generative factors common to two datasets from those specific to each class, the approach swaps only the salient factors to produce counterfactual images, thereby avoiding reliance on classifier decision boundaries. Leveraging StyleGAN2’s high‑quality synthesis and a feature‑space latent representation, the method supports multiple salient factors per dataset and achieves superior counterfactual quality on three medical imaging datasets.
By Yunlong He, Pietro Gori
CausalProfiler is a synthetic benchmark generator designed to evaluate causal machine learning (Causal ML) methods more rigorously and transparently. It randomly samples causal models, data, queries, and ground truths based on explicit design choices across observation, intervention, and counterfactual reasoning levels, providing coverage guarantees and transparent assumptions. The authors demonstrate its utility by testing several state‑of‑the‑art methods under diverse conditions, both within and outside the identification regime, highlighting the insights CausalProfiler can reveal.
By Panayiotis Panayiotou, Audrey Poinsot, Alessandro Leite, Nicolas Chesneau, Marc Schoenauer, \"Ozg\"ur \c{S}im\c{s}ek
arXiv:2607. 14984v1 Announce Type: new Abstract: Per-subgroup fairness audits of medical image classifiers face a sample-size problem: minority subgroups in held-out test sets have so few samples that the resulting confidence intervals on per-subgroup performance are wider than the bias the audit is meant to detect.
By Mahmoud Ibrahim, Bart Elen, Chang Sun, Gokhan Ertaylan, Michel Dumontier
arXiv:2601. 14590v3 Announce Type: replace Abstract: Counterfactual explanations (CFEs) provide human-centric interpretability by identifying the minimal, actionable changes required to alter a machine learning model's prediction.
By Shovito Barua Soumma, Asiful Arefeen, Stephanie M. Carpenter, Melanie Hingle, Hassan Ghasemzadeh
arXiv:2603. 16551v2 Announce Type: replace-cross Abstract: Generative models are increasingly used to augment medical imaging datasets for fairer AI, yet a key assumption often goes unexamined: that generators produce equally high-quality images across demographic groups.
By Mahmoud Ibrahim, Bart Elen, Chang Sun, Gokhan Ertaylan, Michel Dumontier
arXiv:2606. 07865v1 Announce Type: cross Abstract: Scientific machine learning is limited less by model size than by the data it is trained on.
By Daniel N. Wilke
arXiv:2507. 20993v4 Announce Type: replace-cross Abstract: We study how to learn treatment policies from multimodal electronic health records (EHRs) that consist of tabular data and clinical text.
By Henri Arno, Thomas Demeester