arXiv Machine Learning

Explainable Machine Learning in Healthcare: Methods, Interpretation, and Applications for Clinical Research

arXiv:2608. 07522v1 Announce Type: cross Abstract: We present a structured review of commonly used Explainable machine learning (XML) methodologies, including global and local interpretability tools such as SHapley Additive exPlanations (SHAP), Local Interpretable Model-Agnostic Explanations (LIME), Partial Dependence Plots (PDP), and Individual Conditional Expectation (ICE) plots.

arXiv AI

Jul 20

Perception-Aligned AI Outputs: End-to-End Visual Prediction for Uncertainty Communication in Clinical Decision-Making

arXiv:2205. 04599v2 Announce Type: replace-cross Abstract: Explainable Artificial Intelligence (XAI) is essential for trustworthy AI in healthcare, yet many existing methods rely on technical explanations that are difficult for clinicians and patients to interpret.

By Mohammad Eslami, Solale Tabarestani, Saber Kazeminasab, Ehsan Adeli, Glyn Elwyn, Tobias Elze, Mengyu Wang, Nazlee Zebardast, Lucia Sobrin, Nassir Navab, Daniel Shu Wei Ting, Malek Adjouadi

multimodal safety

arXiv Machine Learning

Aug 3

What Is Missing in Surgical Risk Stratification and Outcome Prediction: A Scoping Review of End-to-End Machine Learning Approaches

arXiv:2607. 29090v1 Announce Type: new Abstract: Postoperative adverse events, including mortality and morbidity, remain a major global burden, many of which are preventable through early identification of high-risk patients and targeted perioperative care.

By Yizhi Dong, Yuhe Ke, Hairil Rizal Abdullah, Yucheng Xing, Kevan Kai Bing Teo, Ling Huang, Mengling Feng

multimodal benchmarks

arXiv Machine Learning

Jun 5

Symb-xMIL: Symbolic Explanations for Multiple Instance Learning in Digital Pathology

arXiv:2606. 06224v1 Announce Type: cross Abstract: Explanations of multiple instance learning (MIL) models are widely used for validation and discovery in digital histopathology.

By Yanqing Luo (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Julius Hense (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany), Niklas Preni{\ss}l (Institute of Pathology, Charit\'e Universit\"atsmedizin, Berlin, Germany, Berlin Institute of Health at Charit\'e -- Universit\"atsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\'e Digital Clinician Scientist Program, Berlin, Germany), Andreas Mock (Institute of Pathology, Ludwig Maximilian University of Munich, Munich, Germany, Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany, NCT Heidelberg, Heidelberg, Germany, German Cancer Consortium), Klaus-Robert M\"uller (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany, Department of Artificial Intelligence, Korea University, Seoul, Korea, Max-Planck Institute for Informatics, Saarbr\"ucken, Germany), Thomas Schnake (Department of Chemistry, Chemical Physics Theory Group, University of Toronto, Canada, Vector Institute for Artificial Intelligence, Toronto, Canada, Acceleration Consortium, University of Toronto, Canada), Mina Jamshidi Idaji (Berlin Institute for the Foundations of Learning and Data, Berlin, Germany, Machine Learning Group, Technische Universit\"at Berlin, Berlin, Germany)

safety

arXiv AI

Jun 30

NEURON: A Neuro-symbolic System for Grounded Clinical Explainability

arXiv:2605. 01189v2 Announce Type: replace Abstract: Clinical AI adoption is hindered by the black-box/grey-box nature of high-performing models, which lack the ontological grounding and narrative transparency required for professional-level explainability.

By Anuradha Chandrasekaran, Dimitrios Zikos, Mutlu Mete, Alan Pang, Brady D. Lund, Kewei Sha

llms rag safety

arXiv Machine Learning

Jul 20

A Transportable Threshold-Based Framework for Interpretable Classification of Medical Data

arXiv:2607. 15394v1 Announce Type: new Abstract: Black-box models limit the adoption of artificial intelligence in medicine due to their lack of interpretability and reproducibility.

By Antony Garcia, Adrian Noriega, Gabrielle Britton, Xinming Huang

benchmarks safety

arXiv AI

Sep 16

A unified framework for global and local interpretability using adaptive derivative-ordered random explanation

The paper introduces Adaptive Derivative-Ordered Random Explanation (ADORE), a unified framework that uses first- and second-order derivatives to capture nonlinear feature interactions and feature-sample dynamics. ADORE combines global feature importance with local sample contributions, quantifying both magnitude and direction of feature impact while identifying critical samples. It achieves computational efficiency via randomized SVD and dynamic sparsity detection, outperforming LIME and SHAP across tabular, text, and image data, and is released as an open-source Python package on GitHub.

By Lemen Chao, Ming Lei, Anran Fanga

efficiency safety

arXiv Machine Learning

Aug 21

Explainable Transformer Models for Clinical Prediction Tasks on Structured Electronic Health Records

arXiv:2608. 20315v1 Announce Type: new Abstract: Predictive models over structured electronic health records (EHRs) remain central to machine learning for healthcare, but few have jointly emphasized quantitative laboratory information and interpretability with respect to input medical events.

By Jun Ni Du, Lukas Adamek, Maxim Kryukov, Flavio Dormont, Ziv Bar-Joseph, Sven Jager, Brandon Rufino

llms fine-tuning benchmarks safety

arXiv AI

Jun 18

Language Models as Interfaces, Not Oracles: A Hybrid LLM-ML System for Pediatric Appendicitis

arXiv:2606. 19183v1 Announce Type: cross Abstract: Large language models (LLMs) can make clinical decision support more accessible by interpreting free-text documentation, but their direct use as diagnostic engines is limited by sensitivity to prompts, information order, and plausible but incorrect outputs.

By Soheyl Bateni, Maryam Abdolali

llms safety

arXiv AI

Jul 1

Can Physician Expertise Improve Machine Learning Identification of Delirium?

arXiv:2606. 30651v1 Announce Type: cross Abstract: Delirium is common in hospitalized patients and is often missed in routine care.

By Xinyu Qin, Vicky Ye, Ruiheng Yu, Lu Wang

llms

arXiv AI

Jul 8

X-FEMR: A Token-level Explainable Approach for Electronic Health Records Foundation Models using Transformer-based Models

arXiv:2607. 06163v1 Announce Type: cross Abstract: Foundation Models for Electronic Health Records (FEMRs) are pretrained on large-scale structured patient data, enabling them to convert longitudinal patient trajectories into generalizable representations for diverse clinical prediction tasks.

By Jie Huang, Pengfei Yin, Zihan Xu, Daniel Capurro, Mike Conway, Ting Dang

llms safety

arXiv Machine Learning

Aug 4

xMICD: Explainable Representation of Multiple ICD Codes

arXiv:2608. 00935v1 Announce Type: new Abstract: Electronic Health Records (EHRs) are widely used for clinical risk prediction using machine learning.

By Pat Vatiwutipong, Kumkup Keeratisiwakul, Albert Phuoc Kien Van Truong, Nutcha Yodrabum, Wasin Pansiritanachot, Marvin N. Wright, Thanapon Noraset

rag safety

arXiv Machine Learning

2d ago

Learning to Select Source-Traceable Evidence for Language-Model Prediction from Irregular Clinical Time Series

arXiv:2605.20292v2 Announce Type: replace Abstract: Numerical time-series models effectively process irregular electronic health record (EHR) trajectories, but do not expose which temporal patterns s...

By Kwanhyung Lee, Juhwan Choi, Jongheon Kim, Joohyung Lee, Hyeongwon Jang, Jeonguk Lee, Jisoo Jung, Eunho Yang

llms benchmarks

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