arXiv AI

Foundation Agents Meet Agentic Deep Research: Evidence-Grounded Clinical Code Forecasting

The paper introduces ICD-Deepresearch, a workflow that combines foundation models for electronic health records (EHR) and language models with medical search and ICD dictionaries to forecast future ICD codes for upcoming clinical encounters. It evaluates candidate code transitions by linking patient evidence, external clinical relations, and exact code semantics within a fixed top‑K budget, using SparseEHR for initial priors, GPT‑5 for complementary forecasts, and a final selection step that validates, deduplicates, and ranks candidates. The method achieves patient‑averaged precision/recall of 24.60/35.09% on MIMIC‑III and 25.14/48.32% on MIMIC‑IV, with physicians rating 51–68% of its retrieved documents as useful, outperforming standalone GPT‑5 web search and Medical Deep Research.

arXiv AI
Aug 18

Foresight-England: Development of a National-Scale Generative AI Model of Electronic Health Records for Medical Event Prediction across the COVID-19 Pandemic

arXiv:2608. 16273v1 Announce Type: cross Abstract: Foresight-England (Foresight-E) is the first national-scale generative foundation model of electronic health records (EHRs), developed as a research pilot strictly for COVID-19 research.

By Simon Ellershaw, Christopher Tomlinson, Zeljko Kraljevic, Spiros Denaxas, Harry Hemingway, Cathie Sudlow, Angela M. Wood, Anoop D. Shah, Richard Dobson
arXiv AI
Jul 13

Evaluating Retrieval-Augmented Generation vs. Long-Context Input for Clinical Reasoning over EHRs

arXiv:2508. 14817v2 Announce Type: replace-cross Abstract: Objective: To evaluate whether retrieval-augmented generation (RAG) can serve as an efficient alternative to long-context prompting for clinical reasoning over electronic health records (EHRs).

By Skatje Myers, Dmitriy Dligach, Timothy A. Miller, Samantha Barr, James Landefeld, Yanjun Gao, Matthew Churpek, Anoop Mayampurath, Majid Afshar
arXiv Machine Learning
Jul 20

LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models

arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.

By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv AI
Sep 17

SNOMED CT Concept Recommendation from Masked Clinical Context

The paper introduces a benchmark for recommending SNOMED CT concepts from masked clinical contexts, using data from the SNOMED CT Entity Linking Challenge v1.2.1 derived from MIMIC-IV-Note. It evaluates several methods—including a popularity baseline, sparse TF‑IDF prototypes, dense embeddings, and retrieval‑augmented hybrids—finding that sparse TF‑IDF achieves the best performance with Recall@1 of 14.81% and Recall@10 of 33.43%. The study highlights that concept frequency and lexical context strongly influence recommendation quality, with many test pairs involving concepts unseen during training.

By Ali Noori