The study introduces a graph‑enhanced framework for discovering disease trajectories and forecasting temporal endpoints using longitudinal EHR data from MIMIC‑IV v3.1. It constructs patient‑specific motifs from consecutive admissions, applies a time‑aware Transformer to select up to 24 motifs per endpoint, and reports modest improvements in micro‑AUPRC and event‑time MAE, with larger gains for events occurring after 730 days. The authors also explore branching‑motif conditioning and GNN‑based edge repair, finding that motifs mainly provide long‑range timing support rather than superior endpoint discrimination or survival prediction.
By Jin-Jia Zheng, Vincent S. Tseng
arXiv:2607. 18270v1 Announce Type: new Abstract: While Electronic Health Records (EHRs) offer a wealth of clinical data, effectively augmenting a patient's records with heterogeneous external knowledge to predict the patient's clinical risk remains a significant challenge.
By Kyunghoon Jeon, Youmin Ko, Woohwan Jung, Hyunjoon Kim
arXiv:2609.35549v2 Announce Type: replace
Abstract: Rare-disease diagnosis is a long-tail reasoning problem: phenotypes are incomplete, individual disorders are sparsely documented, and relevant evid...
By Bo Zhang, Yuchen Wang, Dongbai Li, Matthew Yu Heng Wong, Qingkai Zeng, Lijun Wang, Tien-Yin Wong, Peng Cui, Tianyu Liu
arXiv:2608.22062v1 Announce Type: new
Abstract: Longitudinal clinical event-relation verification determines whether a patient record supports a specified relation among two or more clinical events....
By Xingtao Lin, Yubo Feng, Weixin Liu, Hangqi Ren, Junchao Zhou, Caiwan Sun, You Chen
arXiv:2608. 05982v1 Announce Type: new Abstract: Inadequate target--disease linkage accounts for 40--50\% of Phase~II efficacy failures, so anticipating which programmes will advance would let sponsors back the hypotheses most likely to reach patients.
By Pui Chung Siu, Claudia Cabrera, Mani Mudaliar, Arkaitz Zubiaga
arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.
By Zilin Jing, Vincent Jeanselme, Yuta Kobayashi, Simon A. Lee, Chao Pang, Aparajita Kashyap, Yanwei Li, Xinzhuo Jiang, Shalmali Joshi
HADRec is a Hierarchy-Aware Drug Recommendation framework that fuses molecular knowledge and electronic health records to improve medication recommendation. It uses LLaMA-7B to encode clinical notes, ChemBERTa to encode drug SMILES strings, and a cross‑attention mechanism for multimodal fusion, while a hierarchical predictor and consistency constraint loss enforce adherence to the ATC classification system. Experiments on MIMIC‑III and MIMIC‑IV show state‑of‑the‑art performance, strong generalization, and well‑calibrated predictions, with counterfactual evaluation indicating clinically aligned reasoning.
By Junke Wang, Hongshun Ling, Li Zhang, Jinjing Wu, Tong Shao, Fang Wang, Yuan Gao
INTERVenE introduces Transformer models that use a knowledge‑based temporal abstraction (KBTA) token stream of named clinical concepts instead of raw measurements, enabling per‑token attributions to resolve directly to clinical concepts. Two variants are offered: an auto‑regressive decoder that generates future abstraction trajectories with step‑wise risk readouts, and a bidirectional encoder that jointly predicts risk and time‑to‑event in a single pass. On 57,078 MIMIC‑IV admissions, the encoder variant outperforms neural baselines with a support‑weighted AUPRC of 0.672 and AUROC of 0.901, while the decoder provides complementary token‑level risk trajectories.
By Shahar Oded, Yuval Shahar
arXiv:2606. 24102v1 Announce Type: cross Abstract: Most electronic health record (EHR) foundation models encode clinical events as discrete event tokens from a fixed vocabulary and therefore cannot directly represent events containing unseen concepts or new combinations of concepts and attributes such as numeric values.
By Lin Lawrence Guo, Adam Paul Yan, Emily Vettese, Lillian Sung
GraphBEAT is a temporal graph representation learning framework that bucketizes clinical events from longitudinal electronic health records into time‑ordered graphs, enabling early risk stratification for gastrointestinal cancers. It uses a time‑decay message‑passing mechanism and multi‑head attention pooling to generate patient‑level representations, and was trained on multi‑site diagnosis codes and laboratory tests to predict pancreatic, liver, and intestinal cancer at 12, 24, and 36‑month lead times. Across all experiments, GraphBEAT outperformed baseline graph neural networks and sequence models while requiring far fewer floating‑point operations and parameters.
By Leo Y. Li-Han, Chris Varghese, Elizabeth B. Habermann, Mark J. Truty, William R. G. Perry, Cornelius A. Thiels, Hojjat Salehinejad
Background: Disease severity is a multidimensional construct difficult to capture with rule-based approaches in Electronic Healthcare Records (EHR). Agentic large language model (LLM) systems could synthesise clinical evidence and reason over EHRs, but remain unevaluated for this task.
arXiv:2604. 27967v2 Announce Type: replace Abstract: Background: We introduce StructGP, a continuous-time multi-task Gaussian process that couples process convolutions with differentiable structure learning to uncover a sparse, ordered directed acyclic graph (DAG) of inter-variable dependencies while preserving principled uncertainty.
By Ivan Lerner, Jean Feydy, Alexandre Kalimouttou, Anita Burgun, Francis Bach