arXiv:2608. 07796v1 Announce Type: new Abstract: Large language models perform strongly on medical knowledge benchmarks, but reliable clinical deployment requires agents to conduct defensible investigations over heterogeneous, longitudinal records: determining what evidence is needed, retrieving and reconciling structured and free-text data, grounding conclusions in verifiable evidence, and deferring cases that cannot be resolved reliably.
arXiv:2609.39371v1 Announce Type: new Abstract: In hospital workflows, electronic health records (EHRs) are often noisy, and may not contain the evidence needed to confirm events or measurements refe...
Synthetic Hospital is an open, fully synthetic longitudinal electronic health record benchmark created from public medical education material. It contains 1,268 patients and 5,602 encounters, with every diagnosis, finding, and temporal relation grounded in standard ontologies and traceable back to its source. Physicians could not reliably distinguish its records from real charts, and current frontier AI models perform significantly below human experts on tasks such as reconstructing problem lists and summarizing charts.
KnowBench is a new benchmark for clinical AI that measures Effort Reduction (ER), the proportion of system-generated clinical work product accepted by clinicians after expert and safety review. The metric is applied uniformly across various administrative tasks—visit notes, billing codes, orders, EHR summarization, patient summaries, and decision support—using the clinician’s review-and-attestation as ground truth. An initial deployment of Knowtex’s models achieved an aggregate ER of 97.99% across more than one million encounters in six months, with specialty-specific ER ranging from 96.8% to 98.9%.
arXiv:2508. 14817v2 Announce Type: replace-cross Abstract: Objective: To evaluate whether retrieval-augmented generation (RAG) can serve as an efficient alternative to long-context prompting for clinical reasoning over electronic health records (EHRs).
arXiv:2608.23397v1 Announce Type: new Abstract: Interactive clinical agents must gather decisive evidence and convert it into grounded actions under partial observability. A correct final diagnosis a...
arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.
arXiv:2608.22062v1 Announce Type: new Abstract: Longitudinal clinical event-relation verification determines whether a patient record supports a specified relation among two or more clinical events....
The paper introduces a source‑grounded integrity gate for AI‑assisted personal health records, ensuring that data generated by large language models remains provisional until a deterministic monitor verifies it against the source document. The monitor only accepts candidates that contain a unique supporting quotation, appear within the same laboratory row, and preserve provenance, preventing the model from approving its own output. In Medical DataCloud, the system passed all 22 conformance and mutation tests and, in a replay of nine historical lab reports, admitted 72 of 97 numeric candidates while retaining 25 for human review.
arXiv:2604. 14892v3 Announce Type: replace-cross Abstract: Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators.
arXiv:2610.01938v1 Announce Type: cross Abstract: Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integr...
The article proposes a framework called quantitative evidence mining to transform biomedical findings into structured, context-rich evidence units. It outlines core elements such as claim, measured entity, value, comparator, population, conditions, temporal context, uncertainty, provenance, validation, and expert review. The authors present an eight-stage reference architecture and emphasize that plausibility should remain multidimensional rather than collapsed into a single truth label, linking extraction to evidence synthesis for applications like clinical trials, biomarker research, and knowledge-graph construction.
arXiv:2606. 20164v1 Announce Type: cross Abstract: Real-world clinical decision support requires reasoning over heterogeneous and longitudinal patient information rather than answering isolated medical questions.