arXiv Machine Learning

Label-Free Parkinson's Disease Screening from Face and Voice through Mechanistic Interpretability

arXiv:2608. 08976v1 Announce Type: new Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder.

arXiv Machine Learning
Sep 16

BenSParX: A Robust Explainable Machine Learning Framework for Parkinson's Disease Detection from Bengali Conversational Speech

BenSparX introduces the first Bengali conversational speech dataset for Parkinson’s disease detection and pairs it with a robust, explainable machine learning framework. The framework uses diverse acoustic features, systematic feature selection, and advanced classifiers, achieving 95.67% accuracy, 95.62% F1, and 0.990 AUC. SHAP analysis is employed to explain feature contributions, and the model outperforms state‑of‑the‑art methods on other language datasets.

By Riad Hossain, Muhammad Ashad Kabir, Arat Ibne Golam Mowla, Animesh Chandra Roy, Ranjit Kumar Ghosh
arXiv Computation and Language
Sep 21

Cross-Lingual Parkinson's Disease Severity Assessment Using Pre-trained Speech Embeddings: A Multi-Class Evaluation

The paper evaluates pre‑trained speech embeddings from four state‑of‑the‑art speech foundation models for cross‑lingual Parkinson's disease severity assessment. Experiments span three datasets in zero‑shot and k‑shot settings, showing that these embeddings can transfer meaningfully across languages, though performance varies with dataset characteristics, preprocessing, and adaptation strategy. Misclassifications linked to inter‑speaker variability and atypical speech patterns underscore the need for more robust feature extraction, modeling, and explainability to support reliable clinical insights.

By Simon Pals, Cristian Tejedor-Garcia
arXiv AI
Jul 21

A Benchmark for Early-stage Parkinson's Disease Detection from Speech

arXiv:2605. 14066v2 Announce Type: replace-cross Abstract: Early-stage Parkinson's disease (EarlyPD) detection from speech is clinically meaningful yet underexplored, and published results are hard to compare because studies differ in datasets, languages, tasks, evaluation protocols, and EarlyPD definitions.

By Terry Yi Zhong, Cristian Tejedor-Garcia, Khiet P. Truong, Janna Maas, Louis ten Bosch, Bastiaan R. Bloem
arXiv Machine Learning
Jun 18

ActiTect: A Generalizable Machine Learning Pipeline for REM Sleep Behavior Disorder Screening through Standardized Actigraphy

arXiv:2511. 05221v3 Announce Type: replace Abstract: Isolated rapid eye movement sleep behavior disorder (iRBD) is a major prodromal marker of $\alpha$-synucleinopathies, often preceding the clinical onset of Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy.

By David Bertram, Anja Ophey, Sinah R\"ottgen, Konstantin Kufer, Gereon R. Fink, Elke Kalbe, Clint Hansen, Walter Maetzler, Maximilian Kapsecker, Lara M. Reimer, Stephan Jonas, Andreas T. Damgaard, Natasha B. Bertelsen, Casper Skjaerbaek, Per Borghammer, Karolien Groenewald, Pietro-Luca Ratti, Michele T. Hu, No\'emie Moreau, Michael Sommerauer, Katarzyna Bozek
arXiv Computation and Language
6d ago

Why Alzheimer's Speech Screening Fails to Generalize: Bridging the Deployment Gap via Cross-Corpus Evidence Anchoring

The paper examines why speech‑based screening for Alzheimer’s disease fails to generalize across different languages, tasks, and recording protocols. Using a leave‑one‑corpus‑out evaluation on four datasets, it finds that 59 of 70 interpretable speech features show conflicting patterns between healthy controls and cognitive risk groups, with pause, silence, and speech rate being highly protocol‑sensitive. The authors propose a fusion method that combines XLM‑R text baseline scores with evidence anchors, improving mean speaker AUC to 0.785 and worst‑case AUC to 0.615, and emphasize the importance of auditing feature transferability and reporting worst‑case domain robustness.

By Zijian Lu, Sizhe Liu, Yin Zhang, Jixuan Deng, Xinrong Lin, Xinchen Yuan, Chicheng Jin, Yiping Zuo, Yuanchao Li