Label-Free Parkinson's Disease Screening from Face and Voice through Mechanistic Interpretability
arXiv:2608. 08976v1 Announce Type: new Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder.
arXiv:2608. 08976v1 Announce Type: new Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder.
arXiv:2609.14441v1 Announce Type: cross Abstract: Parkinson's disease (PD) manifests early neuromotor impairments that become observable in controlled hand-drawn patterns such as spirals and meanders...
DINO-Med introduces a patch‑based framework that adapts natural‑image foundation models, specifically DINOv3, to multi‑modal medical imaging. The method uses training‑free registration, automated localization, and mask‑filtered patch extraction to aggregate patch‑level features into subject‑level diagnostics. In liver fibrosis staging, DINOv3 outperforms handcrafted radiomics, ResNet, and SAM‑Med2D features, achieving 78.4% accuracy for mild fibrosis (S1) and 75.8% for cirrhosis (S4) on the CARE 2025 cohort.
arXiv:2606. 07135v1 Announce Type: new Abstract: Huntington's disease (HD) is a progressive neurodegenerative disorder that affects motor, cognitive, and behavioral functions, where accurate characterization of disease progression remains essential to improve patient outcome and quality of life.
The paper introduces DINO-Med, a patch‑based framework that adapts natural‑image foundation models to multi‑modal medical imaging, specifically for liver fibrosis staging. It processes raw multimodal scans through training‑free registration, automated localization, and mask‑filtered patch extraction, then aggregates patch‑level insights into subject‑level diagnostics. Using the CARE 2025 Liver Track 4 cohort, the DINOv3‑based approach achieved the highest classification accuracy (78.4% for mild fibrosis and 75.8% for cirrhosis) compared to other feature representations.
arXiv:2511. 05221v3 Announce Type: replace Abstract: Isolated rapid eye movement sleep behavior disorder (iRBD) is a major prodromal marker of $\alpha$-synucleinopathies, often preceding the clinical onset of Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy.
arXiv:2606. 09271v1 Announce Type: cross Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder that frequently causes speech impairments associated with hypokinetic dysarthria.
arXiv:2509. 16727v5 Announce Type: replace-cross Abstract: Automated pain assessment from facial expressions is crucial for non-communicative patient.
arXiv:2604. 19191v2 Announce Type: replace-cross Abstract: Deploying AI-based anomaly detection across diverse clinical imaging settings remains challenging because most existing methods rely on modality-specific architectures, anatomical priors, or extensive retraining, limiting their use as general-purpose screening tools.
arXiv:2607. 05585v1 Announce Type: cross Abstract: FaceMesh2HPO is a framework for classifying facial phenotypic descriptors aligned with the Human Phenotype Ontology (HPO) to support clinical diagnosis.
The paper evaluates pre‑trained speech embeddings from four state‑of‑the‑art speech foundation models for cross‑lingual Parkinson's disease severity assessment. Experiments span three datasets in zero‑shot and k‑shot settings, showing that these embeddings can transfer meaningfully across languages, though performance varies with dataset characteristics, preprocessing, and adaptation strategy. Misclassifications linked to inter‑speaker variability and atypical speech patterns underscore the need for more robust feature extraction, modeling, and explainability to support reliable clinical insights.
arXiv:2607. 18882v1 Announce Type: cross Abstract: Validating Explainable Artificial Intelligence (XAI) methods in medical imaging requires ground-truth data with known locations of informative features.