Flexible Flows for Biological Sequence Design
arXiv:2606. 10543v1 Announce Type: cross Abstract: Designing functional biological sequences requires navigating vast discrete spaces under strict evolutionary and biophysical constraints.
arXiv:2606. 07400v1 Announce Type: new Abstract: Many scientific problems require inferring unobserved mechanistic latent states from indirect observations.
arXiv:2606. 10543v1 Announce Type: cross Abstract: Designing functional biological sequences requires navigating vast discrete spaces under strict evolutionary and biophysical constraints.
arXiv:2310.04363v3 Announce Type: replace Abstract: Autoregressive large language models (LLMs) compress knowledge from their training data through next-token conditional distributions. This limits t...
arXiv:2506. 03672v2 Announce Type: replace-cross Abstract: Combinatorial Optimization problems are widespread in domains such as logistics, manufacturing, and drug discovery, yet their NP-hard nature makes them computationally challenging.
arXiv:2606. 15458v1 Announce Type: cross Abstract: Variational inference (VI) is a core engine of modern AI, enabling scalable approximate Bayesian learning and uncertainty-aware training of large probabilistic and generative models.
arXiv:2609.37381v1 Announce Type: new Abstract: Neural simulation-based inference (SBI) has been widely successful in inferring a relatively small number of interpretable parameters from potentially...
arXiv:2608.31028v1 Announce Type: cross Abstract: Scientific discovery often requires reasoning over competing hypotheses that are consistent with experimental observations. For mixed-variable and co...
arXiv:2606. 02133v1 Announce Type: cross Abstract: Non-monotonic sequence generation methods, such as masked diffusion models, provide a flexible alternative to left-to-right autoregressive modeling by allowing tokens to be generated in non-fixed and prescribed orders.
arXiv:2602. 17162v3 Announce Type: replace Abstract: Genomic Foundation Models (GFMs) typically rely on Masked Language Modeling (MLM) or Next-Token Prediction (NTP) to learn the "Laws of Nature".
arXiv:2606. 00934v1 Announce Type: cross Abstract: Network data are ubiquitous across the social sciences, biology, and information systems.
Scientific discovery often requires reasoning over competing hypotheses that are consistent with experimental observations. For mixed-variable and combinatorial hypothesis spaces, however, constructin...
arXiv:2608.29335v1 Announce Type: new Abstract: Latent generative models typically follow a two-stage pipeline, training a variational autoencoder for reconstruction and then a generative model on th...
ProtoFlow is a new multivariate time series forecasting framework that combines vector‑quantized autoencoding with prototype‑guided flow matching. It maps sequences into a discrete latent space, constructs a structured prior from the learned VQ codebook, and trains a DiT‑based rectified flow to transport samples from this prior to future latent representations conditioned on past observations. By replacing generic Gaussian noise with a learned prototype prior, ProtoFlow eliminates autoregressive rollout mismatch and achieves faster training convergence while delivering superior forecasting performance on benchmark datasets.