arXiv:2604. 07848v2 Announce Type: replace Abstract: Multi-task learning shows strikingly inconsistent results -- sometimes joint training helps substantially, sometimes it actively harms performance -- yet the field lacks a principled framework for predicting these outcomes.
arXiv:2607. 16554v1 Announce Type: cross Abstract: In multi-task learning (MTL) negative transfer is often considered as an optimization artifact, but it can also be viewed as a consequence of limited shared capacity and weak task redundancy.
The paper introduces COVER, a multi‑task learning framework that regularizes covariate overlap to mitigate the negative effects of sharing information across tasks with differing covariate distributions and response relationships. COVER blends a common component function, a shared neural representation, and low‑dimensional task‑specific coefficients, using taskwise second‑moment matrices to guide coefficient integration. The authors provide theoretical bias‑variance analysis, oracle inequalities, and neural‑network convergence rates, and demonstrate that COVER outperforms existing deep‑learning and statistical integration methods in simulations and a GTEx central‑nervous‑system study.
arXiv:2607. 00995v1 Announce Type: cross Abstract: Most existing multitask learning approaches are limited by their reliance on task-specific loss functions tailored to the scale and type of each outcome.
BrainWideBench is a benchmark that evaluates across‑animal transfer on multi‑region neural recordings from 139 mice, covering 276 brain regions. It comprises three task suites—behavior decoding, neural activity prediction, and anatomical organization recovery—to test whether learned representations support diverse downstream objectives. The benchmark shows that while pretraining improves performance over single‑session baselines, current methods vary in transfer ability and none perform uniformly well across all suites, highlighting the challenge of developing general‑purpose neural representations.
MT-ProtBERT is a multi‑task extension of ProtBERT designed for classifying intrinsically disordered proteins (IDPs) in low‑data settings. It combines Dynamic Window Masking, a Multi‑Scale 1D Convolutional classifier, and auxiliary biochemistry‑informed objectives to jointly optimize masked language modeling and domain‑specific tasks. In experiments on phosphorylation site prediction and protein compaction prediction, MT‑ProtBERT outperforms the RNN‑based IDP model PARROT across all limited‑data tasks.
The paper introduces a theoretically grounded multi‑task learning framework, AMTIDIN, for joint interference detection, modulation identification, and interference identification. It derives an upper bound linking MTL performance to task similarity measured by Wasserstein distance and adaptive coefficients, and employs adversarial training to reduce distributional gaps across tasks. Experiments show AMTIDIN outperforms single‑task models and other MTL baselines, especially when training data is limited, signals are short, and SNRs are low.
arXiv:2607. 03103v1 Announce Type: cross Abstract: Clinical cardiac imaging pipelines currently deploy separate models for each dataset and modality, incurring redundant training costs and precluding knowledge sharing across anatomically related tasks.
arXiv:2606. 02221v1 Announce Type: cross Abstract: Multi-task learning (MTL) aims to construct a joint model for multiple tasks by sharing a common representation across domains.
arXiv:2606. 11508v1 Announce Type: new Abstract: Accurate prediction of absorption, distribution, metabolism, and excretion (ADME) properties is critical to drug discovery, but remains challenging because ADME endpoints are noisy, interdependent, and often data-limited.
Antimicrobial peptides (AMPs) often act against multiple pathogen classes, making multi-label activity prediction a more realistic screening target than binary antimicrobial classification. The ESCAPE...
ProbeMatchDTI is a new framework for drug‑target interaction prediction that uses probe‑driven pattern matching to preserve weak biochemical signals. It introduces IterProbe, which retains contextual states across refinement depths and selects them with learnable probes, and BindingProbe, which models drug‑protein complementarity at both local and whole‑pair levels. Experiments show that ProbeMatchDTI outperforms existing methods, improving AUC‑ROC by 2.0% on BindingDB and 0.5% on DrugBank, and its predictions can be integrated into downstream drug‑discovery workflows.
arXiv:2606. 27242v1 Announce Type: new Abstract: Training-free source selection for LLM families with shared vocabularies arises in scientific string domains such as SMILES, protein, and genomic sequences, where candidate corpora share a tokenizer but differ in prediction targets.