Multi-Task Learning with Covariate-Overlap Regularization

The paper introduces COVER, a multi‑task learning framework that regularizes covariate overlap to mitigate the negative effects of sharing information across tasks with differing covariate distributions and response relationships. COVER blends a common component function, a shared neural representation, and low‑dimensional task‑specific coefficients, using taskwise second‑moment matrices to guide coefficient integration. The authors provide theoretical bias‑variance analysis, oracle inequalities, and neural‑network convergence rates, and demonstrate that COVER outperforms existing deep‑learning and statistical integration methods in simulations and a GTEx central‑nervous‑system study.

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