arXiv:2511. 17605v2 Announce Type: replace Abstract: Clinical and gene-expression models predict breast cancer outcomes, but simple linear fusion ignores dependence between their risk scores.
arXiv:2607. 16250v1 Announce Type: cross Abstract: Estrogen Receptor (ER) status is a critical biomarker in breast cancer diagnosis, prognosis, and treatment selection.
The study benchmarks active spot selection methods against random sampling for spatial transcriptomics, focusing on cost‑efficient data acquisition. Using two public cohorts, the authors simulate multi‑round selection with uncertainty‑based (MC‑dropout, TOD) and diversity‑based (CoreSet, TypiClust) strategies, evaluating performance at 5%, 10%, 30%, and 50% of the spot pool. Results show that none of the active strategies consistently outperforms random sampling across all budgets or evaluation metrics, with performance varying by dataset and metric.
The paper presents Copula Adapted Directed Acyclic Graph (CopDAG), a framework that combines copula models with an ensemble of causal structure discovery methods based on Directed Acyclic Graphs to represent biomedical data. By capturing non‑Gaussian, non‑linear dependencies and stable causal relationships, CopDAG enables clustering of unlabeled biomedical data using K‑means. Across 16 biomedical datasets, CopDAG achieves the highest normalized clustering accuracy and adjusted Rand index among 12 evaluated methods, and it can predict class labels and provide explainable causal visualizations without relying on data annotations.
arXiv:2609.38181v1 Announce Type: new Abstract: Survival analysis estimates time-to-event outcomes from patient covariates and is widely used for medical risk assessment. Patients seeking prognostic...
arXiv:2608. 00271v1 Announce Type: cross Abstract: A wide range of statistical and machine learning methods have been proposed for survival analysis with competing risks, where the occurrence of one event (i.
arXiv:2608. 04025v1 Announce Type: cross Abstract: Whole-slide survival models commonly provide risk rankings without calibrated statements about individual event times.
arXiv:2403. 00965v2 Announce Type: replace-cross Abstract: Only a small fraction of patients with chronic kidney disease (CKD) progress to dialysis, creating severe class imbalance that limits the performance of machine learning models for early dialysis prediction.
arXiv:2410. 00945v2 Announce Type: replace-cross Abstract: Gene-expression profiling is widely used in research and central to many areas of precision oncology, but remains costly and not universally accessible.
The paper introduces FCA‑Guided Counterfactual (FCA‑CF) explanations for multi‑modal breast cancer diagnosis, leveraging a Formal Concept Analysis lattice as a hard structural constraint to search for counterfactuals. On the TCGA‑BRCA dataset, FCA‑CF achieves perfect validity (100% prediction flips), the lowest average feature changes (2.37), and competitive proximity (0.900) compared to four other methods. Ablation studies show the lattice constraint drives sparsity, while a greedy refinement phase further improves results.
A causal multi-modal AI model was developed to predict personalized chemosensitivity in breast cancer patients using routine pathology and clinical data. Trained on 9,141 patients from nine countries and validated on 1,994 patients from three countries, the model produced treatment-specific recurrence probabilities with near-perfect calibration and strong prognostic discrimination over 5- and 10-year horizons. It outperformed existing recurrence-score tests and could reduce chemotherapy prescriptions by 30% while maintaining recurrence-free rates, with predictive performance also transferring to non-breast cancers.
arXiv:2609.26443v1 Announce Type: new Abstract: Recent advances in Artificial Intelligence (AI)-powered Computer-Aided Diagnosis (CAD) systems have substantially improved breast cancer screening, dia...
arXiv:2608. 04046v1 Announce Type: cross Abstract: Survival analysis is an established framework for analyzing time-to-event data, yet many clinical machine learning studies still binarize the outcome before model training.