The paper examines how residual misalignments from registration procedures introduce structured label noise in supervised synthetic CT (sCT) generation. It shows that voxel‑wise metrics are heavily influenced by the consistency between training and evaluation registrations, and that training with anatomically consistent registrations reduces variability and improves robustness. Introducing a perceptual loss based on a pretrained Segment Anything encoder yields sharper, more anatomically coherent sCT and highlights the need for anatomy‑oriented evaluation.
By Valentin Boussot, Cedric Hemon, Caroline Lafond, Jean-Claude Nunes, Jean-Louis Dillenseger
The study explores how adding anatomical priors and active learning can improve the accuracy of deep learning models for segmenting the Clinical Target Volume (CTV) in gastric cancer radiotherapy. Using 100 retrospective CT scans, an nnU‑Net model trained on 10 expert‑contoured cases was enhanced with voxel‑wise anatomical prior maps and iterative active learning over four rounds. The combined approach raised the mean Dice Similarity Coefficient from 0.84 to 0.87, demonstrating that both techniques individually and together improve segmentation performance and generalizability.
By Phillip Chlap, Mark Lee, Trevor Leong, Matthew Field, Jason Dowling, Hang Min, Julie Chu, Jennifer Tan, Phillip K. Tran, Tomas Kron, Annette Haworth, Martin A. Ebert, Shalini K. Vinod, Lois Holloway
CMRVision is a cardiac magnetic resonance (CMR) foundation model trained with DINOv3-style self‑supervised learning on 36 million multi‑center, multi‑sequence CMR images. It outperforms prior natural‑image, medical‑image, supervised, and CMR baselines on multi‑task segmentation (cine, LGE, mapping) and cine view classification, achieving Dice scores of 0.940–0.967 for LV and 0.855–0.905 for myocardium, and a zero‑shot Dice of 0.692 on unseen LGE long‑axis views. The model demonstrates robust cross‑view generalization and highest average accuracy (0.906) for cine view classification.
By Athira J. Jacob, Puneet Sharma, Daniel Rueckert
DALE-CT introduces depth‑aware 2D slice encoders that learn an anatomical world model of chest CT scans without 3D or positional supervision. By sampling self‑supervised views across a physical $z$‑axis slab, the encoder captures how anatomy changes between neighboring slices, enabling it to recover slice ordering and distinguish slices by anatomy alone. The model, trained on a large 287k‑scan corpus, achieves state‑of‑the‑art performance on CT‑RATE and is released with full code and evaluation tools.
By Evan W. Damron, Mahmut S. Gokmen, Mitchell A. Klusty, Caroline N. Leach, Emily B. Collier, V. K. Cody Bumgardner
arXiv:2609.25743v1 Announce Type: new
Abstract: Interactive segmentation of 3D medical images supports quantitative analysis of anatomical structures and disease while allowing users to specify and r...
By Ping Gong, Shiyuan Su, Fandong Zhang, Xinchen Han, Haowei Sun, Yiming Li, Yizhou Yu
arXiv:2606. 15457v1 Announce Type: cross Abstract: 3D FLAIR MRI is widely recommended as one of the standard MRI sequences for brain imaging in multiple sclerosis (MS), but publicly available MS datasets remain relatively small and vary across scanners, acquisition protocols, and lesion patterns.
By Weidong Zhang, Yongchan Jung, Shafayat Mowla Anik, Furen Xiao, Vasudevan Janarthanan, Enkhzaya Chuluunbaatar, Byeong Kil Lee, Jeeho Ryoo
The paper introduces a geometry‑guided sampling operator that directs feature sampling rather than altering convolution kernels in 3D encoder‑decoder networks. By predicting local orientations and bounded step sizes, the operator samples symmetrically around each voxel, generating compact geometric and boundary cues that improve fine‑structure segmentation. Replacing stride‑1 and stride‑2 operations in a 3D U‑Net yields consistent gains on BraTS, MSD Hepatic Vessel, and TDSC‑ABUS datasets, with better boundary metrics and fewer parameters, and the operator can be integrated into other backbones without architectural changes.
By Sizhe Wang, Himashi Peiris, Zhaolin Chen
Foundation models such as Segment Anything Model 2 (SAM2) have transformed natural-image and video segmentation, and recent work has begun adapting them to medical imaging. These adaptations, however, are largely general-purpose models that treat MRI as one modality among many; large-scale, MRI-specific modelling and benchmarking remain limited, even though MRI's low soft-tissue contrast leaves many boundaries effectively invisible on individual slices.
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
By Muge Zhang, Muhammad Ali Khaliq, Jamal Alsakran, Byeong Kil Lee, Jeeho Ryoo
arXiv:2606. 15370v1 Announce Type: cross Abstract: This work demonstrates a full reproduction and extension of MNet, a hybrid 2D/3D convolutional network designed for anisotropic medical image segmentation.
By Kirsten Odendaal, Rade Bajic
arXiv:2606. 19651v1 Announce Type: new Abstract: Three-dimensional (3D) brain MRI is central to clinical neurology and neuro-oncology, where generative models could augment under-represented cohorts, simulate disease trajectories, and support privacy-preserving data sharing.
By Max Van Puyvelde, Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
The paper introduces an unsupervised approach to medical image segmentation by training a Denoising Diffusion Probabilistic Model (DDPM) on 21 unlabeled abdominal CT scans to learn anatomical features. The encoder weights from the DDPM are transferred to a U‑Net for downstream segmentation on the BTCV multi‑organ dataset, resulting in a significant Dice score improvement for liver segmentation from 0.75 to 0.93. In low‑data regimes, diffusion‑pretrained models retain robust performance, achieving high Dice scores even with only 10% of labeled data.
By Akshat G, Divyansh Gupta, Shaleen Bhatnagar, Shilpa Ankalaki, Tusar Kanti Mishra