arXiv:2602. 04119v2 Announce Type: replace Abstract: The application of generative models for experimental drug discovery campaigns is severely limited by the difficulty of designing molecules de novo that can be synthesized in practice.
By Hyeonah Kim, Minsu Kim, Celine Roget, Dionessa Biton, Louis Vaillancourt, Yves V. Brun, Yoshua Bengio, Alex Hernandez-Garcia
arXiv:2606. 07610v1 Announce Type: cross Abstract: State-of-the-art GRPO-style methods for speech-aware large language model post-training suffer from coarse credit assignment, broadcasting the same terminal-reward advantage to every token in a response.
By Argyrios Gerogiannis, Yekaterina Yegorova, Mark Hasegawa-Johnson, Venugopal V. Veeravalli
arXiv:2602. 21565v3 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) learn to sample diverse candidates in proportion to a reward function, making them well-suited for scientific discovery, where exploring multiple promising solutions is crucial.
By Seokwon Yoon, Youngbin Choi, Seunghyuk Cho, Seungbeom Lee, MoonJeong Park, Dongwoo Kim
arXiv:2606. 16847v1 Announce Type: cross Abstract: Diffusion Large Language Models (dLLMs) offer a promising avenue for parallel generation but face a trade-off between decoding speed and quality.
By Yizhen Yao, Qinglin Zhu, Runcong Zhao, Xiangxiang Dai, Yanzheng Xiang, Yulan He, Lin Gui
arXiv:2509. 26405v2 Announce Type: replace Abstract: We introduce InVirtuoGen, a discrete flow generative model for fragmented SMILES for de novo and fragment-constrained generation, and target-property/lead optimization of small molecules.
By Benno Kaech, Luis Wyss, Karsten Borgwardt, Gianvito Grasso
arXiv:2605. 01729v2 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) learn to sample states proportional to an unnormalized reward.
By Zengxiang Lei, Ananth Shreekumar, Jonathan Rosenthal, Ruoyu Song, Alvaro A. Cardenas, Daniel J. Fremont, Dongyan Xu, Satish Ukkusuri, Z. Berkay Celik
arXiv:2602. 14169v2 Announce Type: replace-cross Abstract: Effective exploration is a key challenge in reinforcement learning for large language models: discovering high-quality trajectories within a limited sampling budget from the vast natural language sequence space.
By Yiran Guo, Zhongjian Qiao, Yingqi Xie, Jie Liu, Dan Ye, Ruiqing Zhang, Shuang Qiu, Lijie Xu
arXiv:2607. 19395v1 Announce Type: cross Abstract: Small language models are attractive backbones for interactive agents, but direct distillation from strong teacher trajectories often turns rich multi-turn behavior into one-shot imitation targets.
By Yihan Wang, Zhong Guan, Haoran Sun, Jiale Huang, Likang Wu, Hongke Zhao
arXiv:2602. 17162v3 Announce Type: replace Abstract: Genomic Foundation Models (GFMs) typically rely on Masked Language Modeling (MLM) or Next-Token Prediction (NTP) to learn the "Laws of Nature".
By Ariel Larey, Elay Dahan, Amit Bleiweiss, Raizy Kellerman, Guy Leib, Omri Nayshool, Dan Ofer, Tal Zinger, Dan Dominissini, Gideon Rechavi, Nicole Bussola, Simon Lee, Shane O'Connell, Dung Hoang, Marissa Wirth, Alexander W. Charney, Nati Daniel, Yoli Shavit
arXiv:2607. 13394v1 Announce Type: cross Abstract: Generative Flow Networks (GFlowNets) offer a promising alternative to reward-maximizing reinforcement learning (RL) for large reasoning models, encouraging diverse reasoning paths by matching reward distributions rather than collapsing to dominant modes.
By Xiaodong Liu, Michael Xu, Jack W. Stokes, Paul Smolensky, Doug Burger, Jianfeng Gao
arXiv:2608. 15062v1 Announce Type: cross Abstract: Scaling transformer language models creates an inherent tension between expressivity and memory efficiency.
By Amr Hegazy, Amr Alanwar, Mostafa Elhoushi
arXiv:2607. 11505v1 Announce Type: cross Abstract: Post-training is essential for refining the domain-specific capabilities of large language models (LLMs), yet existing reward optimization and distribution matching methods tightly couple policy exploration with distribution alignment.
By Daocheng Fu, Rong Wu, Yu Yang, Xuemeng Yang, Jianbiao Mei, Licheng Wen, Pinlong Cai, Yong Liu, Botian Shi, Yu Qiao