arXiv:2603. 00454v3 Announce Type: replace-cross Abstract: Generative Flow Networks (GFlowNets) enable fine-tuning large language models to approximate reward-proportional posteriors, but they remain prone to mode collapse, manifesting as prefix collapse and length bias.
arXiv:2605.01513v2 Announce Type: replace Abstract: Designing therapeutic messenger RNA (mRNA) requires generating full-length transcripts that optimally balance intracellular stability and translati...
The paper introduces a new learning objective called trajectory balance for Generative Flow Networks (GFlowNets), aiming to improve credit assignment across long action sequences. It demonstrates that minimizing this objective yields a policy that samples exactly from the target distribution. Experiments on four domains show that trajectory balance enhances convergence, sample diversity, and robustness to long sequences and large action spaces.
arXiv:2602. 04119v2 Announce Type: replace Abstract: The application of generative models for experimental drug discovery campaigns is severely limited by the difficulty of designing molecules de novo that can be synthesized in practice.
arXiv:2602. 21565v3 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) learn to sample diverse candidates in proportion to a reward function, making them well-suited for scientific discovery, where exploring multiple promising solutions is crucial.
CocoRNA is a cooperative multi-agent reinforcement learning framework that tackles RNA inverse design by breaking the problem into smaller sub‑problems solved collaboratively by multiple agents. A centralized critic provides global structural guidance during training, allowing the agents to jointly optimize their design strategies. Experiments on the Rfam dataset show that CocoRNA outperforms state‑of‑the‑art methods in both success rate and design speed, and additional tests on other biological sequence design tasks demonstrate its broad effectiveness.
arXiv:2609.36885v1 Announce Type: cross Abstract: RNA design aims to identify sequences that fold into specified secondary structures. Existing methods formulate the task as target-specific search or...
arXiv:2506. 07459v4 Announce Type: replace Abstract: Protein generative models have shown remarkable promise in protein design, yet their success rates remain constrained by reliance on curated sequence-structure datasets and by misalignment between supervised objectives and real design goals.
arXiv:2408. 05885v3 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) have been shown effective to generate combinatorial objects with desired properties.
arXiv:2606. 24679v1 Announce Type: cross Abstract: Data preparation pipelines improve data quality in machine learning by transforming raw tables into learning-ready data through sequential cleaning and feature transformation operators.
Predictor-Guided Latent Space Codon Optimization (LSCO) transforms the discrete codon selection problem into a continuous optimization task by embedding sequences into the latent space of a pretrained mRNA language model, allowing gradient-based search. LSCO integrates a data-driven expression objective from an uncertainty-aware predictor, a Minimum-Free-Energy regularizer for structural stability, a naturalness prior derived from a protein-to-codon back-translation model, and constrained decoding to preserve protein fidelity. In a real-world wet-lab antibody expression dataset, LSCO outperforms both simple frequency-based methods and modern deep generative baselines in predicted expression while maintaining appropriate biophysical properties.
arXiv:2609.38359v1 Announce Type: new Abstract: High quality synthetic data is central to post training LLMs for adaptive AI applications that represent the diverse expert strategies and decisions in...