arXiv Machine Learning
Curriculum-Augmented GFlowNets For mRNA Sequence Generation
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arXiv AI
Jul 21
Rooted Absorbed Prefix Trajectory Balance with Submodular Replay for GFlowNet Training
arXiv:2603. 00454v3 Announce Type: replace-cross Abstract: Generative Flow Networks (GFlowNets) enable fine-tuning large language models to approximate reward-proportional posteriors, but they remain prone to mode collapse, manifesting as prefix collapse and length bias.
arXiv Machine Learning
20h ago
ProMORNA: An End-to-End Generative Framework for Full-Length mRNA Design
arXiv:2605.01513v2 Announce Type: replace Abstract: Designing therapeutic messenger RNA (mRNA) requires generating full-length transcripts that optimally balance intracellular stability and translati...
arXiv Machine Learning
Aug 31
Trajectory balance: Improved credit assignment in GFlowNets
The paper introduces a new learning objective called trajectory balance for Generative Flow Networks (GFlowNets), aiming to improve credit assignment across long action sequences. It demonstrates that minimizing this objective yields a policy that samples exactly from the target distribution. Experiments on four domains show that trajectory balance enhances convergence, sample diversity, and robustness to long sequences and large action spaces.
arXiv Machine Learning
Jun 10
Synthesizable Molecular Generation via Soft-constrained GFlowNets with Rich Chemical Priors
arXiv:2602. 04119v2 Announce Type: replace Abstract: The application of generative models for experimental drug discovery campaigns is severely limited by the difficulty of designing molecules de novo that can be synthesized in practice.
arXiv Machine Learning
Jul 21
Routing by Reaching: Composition of Pre-trained GFlowNets for Multi-Objective Generation
arXiv:2602. 21565v3 Announce Type: replace Abstract: Generative Flow Networks (GFlowNets) learn to sample diverse candidates in proportion to a reward function, making them well-suited for scientific discovery, where exploring multiple promising solutions is crucial.
arXiv Machine Learning
3d ago
CocoRNA: Collective RNA Design with Cooperative Multi-agent Reinforcement Learning
CocoRNA is a cooperative multi-agent reinforcement learning framework that tackles RNA inverse design by breaking the problem into smaller sub‑problems solved collaboratively by multiple agents. A centralized critic provides global structural guidance during training, allowing the agents to jointly optimize their design strategies. Experiments on the Rfam dataset show that CocoRNA outperforms state‑of‑the‑art methods in both success rate and design speed, and additional tests on other biological sequence design tasks demonstrate its broad effectiveness.